From inflammation to colitis-associated colorectal cancer in inflammatory bowel disease: Pathogenesis and impact of current therapies

MC Fantini, I Guadagni - Digestive and Liver Disease, 2021 - Elsevier
inflammatory bowel disease (IBD). Population-based data from patients with ulcerative colitis
(… with Crohn's disease appear to have a similar increased risk. However, the true extent of …

Diagnosis and management of inflammatory bowel disease-associated neoplasia: considerations in the modern era

JE Axelrad, SC Shah - Therapeutic advances in …, 2020 - journals.sagepub.com
… The focus of this review is on the pathogenesis, … found in inflamed ileal segments with
previous or synchronous ileal dysplasia, suggesting that inflammation-associated SBC may evolve

Sex matters: impact on pathogenesis, presentation and treatment of inflammatory bowel disease

WA Goodman, IP Erkkila, TT Pizarro - Nature Reviews Gastroenterology …, 2020 - nature.com
… and their dependents. The study found that the prevalence of ulcerative colitis and Crohn’s …
In particular, OCP-exposed women with IBD might consider changing their mode of …

Dysbiosis in inflammatory bowel disease: pathogenic role and potential therapeutic targets

PT Santana, SLB Rosas, BE Ribeiro, Y Marinho… - International journal of …, 2022 - mdpi.com
… in the study of inflammatory bowel disease (IBD) pathogenesis. … were microbes, and they
have evolved and adapted to live in … established, evidence indicating an association with IBD …

Revisiting inflammatory bowel disease: pathology, treatments, challenges and emerging therapeutics including drug leads from natural products

K Yeshi, R Ruscher, L Hunter, NL Daly… - Journal of clinical …, 2020 - mdpi.com
… of inflammation, implicating its role in the pathogenesis of IBD… are drugs developed with
maximum similarity to their original … have successfully co-evolved with their human hosts through …

Interleukin-23 in the pathogenesis of inflammatory bowel disease and implications for therapeutic intervention

GW Sewell, A Kaser - Journal of Crohn's and Colitis, 2022 - academic.oup.com
It is well established that CD and UC have a substantial genetic component, and GWAS have
… This includes FAMIN, an evolutionary conserved multifunctional enzyme that through its

Pathway paradigms revealed from the genetics of inflammatory bowel disease

DB Graham, RJ Xavier - Nature, 2020 - nature.com
… in our understanding of IBD pathogenesis that provide insights … evolve into a CD-like disease
associated with ileal pouch … are being developed to mimic intestinal biology in vitro in gut-on…

The role of diet in the pathogenesis and management of inflammatory bowel disease: a review

G Wark, D Samocha-Bonet, S Ghaly, M Danta - Nutrients, 2020 - mdpi.com
… The microbiome, defined as the collection of microbes and their genes found in their host …
A study compared changing dietary intake and incidence of CD in a homogenous Japanese …

Changing global epidemiology of inflammatory bowel diseases: sustaining health care delivery into the 21st century

AN Ananthakrishnan, GG Kaplan, SC Ng - Clinical Gastroenterology and …, 2020 - Elsevier
implications from improving the understanding of the pathogenesis of IBD to highlighting
the evolvingIt was found that elevated fecal calprotectin was significantly associated with a …

Colorectal cancer in inflammatory bowel disease: mechanisms and management

SC Shah, SH Itzkowitz - Gastroenterology, 2022 - Elsevier
their role in the pathogenesis and behavior of inflammation-… Although smoking is an established
risk factor in sCRC, it is … , in addition to its effect of increasing bile flow and changing the …