Upregulation of the protein kinase Lyn is associated with renal injury in type 2 diabetes patients

J Chen, L Peng, J Sun, J Liu, L Chu, B Yi, M Gui… - Renal …, 2023 - Taylor & Francis
… with diabetic kidney disease (DKD) and in kidney tissues of streptozotocin (STZ)-induced
DKD mice. … that administration of the Src family kinase inhibitor PP2 decreases proteinuria and …

Angiotensin II as a mediator of renal fibrogenesis

I Loeffler, G Wolf - Angiotensin, 2023 - Elsevier
… of APA in mouse mesangial cells attenuated the proliferative … to aggravation of diabetic
nephropathy in mice in comparison … the glucose-induced PRR translocation to the apical cell side …

[HTML][HTML] Pathophysiological impact of the MEK5/ERK5 pathway in oxidative stress

I Tusa, A Menconi, A Tubita, E Rovida - Cells, 2023 - mdpi.com
… Otsuka Long Evans Tokushima Fatty rats, which display diabetic nephropathy at 52 weeks
of age. High glucose-induced ERK5 activation in cultured rat mesangial cells was reduced by …

[HTML][HTML] Gene deficiency or pharmacological inhibition of PDCD4-mediated FGR signaling protects against acute kidney injury

X Jing, D Ren, F Gao, Y Chen, X Wu, Y Han… - … Pharmaceutica Sinica B, 2021 - Elsevier
… a tyrosine kinase inhibitor, significantly ameliorated AKI in mice. … parenchymal cells including
rat glomerular mesangial cells (… of the SRC family of non-receptor tyrosine kinases, but was …

Network Toxicology and Cell Experiments Reveal the Mechanism of Dehp-Induced Diabetic Nephropathy Via Wnt Signaling Pathway

X Hu, Y Yin, P Xu, M Wei, W Zhang - Available at SSRN 4827212 - papers.ssrn.com
Inhibition of Src kinase blocks high glucose-induced EGFR transactivation 538 and
collagen synthesis in mesangial cells and prevents diabetic

… factor receptor in hypothalamic paraventricular nucleus reduces extracellular signal-regulated kinase 1 and 2 signaling and sympathetic excitation in heart failure rats

Y Yu, SG Wei, RM Weiss, RB Felder - Neuroscience, 2021 - Elsevier
… -induced MAPK signaling, and MAPK-mediated production of IL-1β and TNF-α (Qu et …
inhibition of ERK1/2 signaling was most effective in preventing EGFR-mediated cytokine production

[HTML][HTML] Exploring the Potential Lipid-Lowering and Weight-Reducing Mechanisms of FH06 Fermented Beverages Based on Non-Targeted Metabolomics and …

H Wang, T Wang, J Wang, R Liu, Y Cui, X Wu, R Dai… - Fermentation, 2024 - mdpi.com
diabetic nephropathy. This study revealed that the phosphorylation of Sre in mesangial cells
stimulated by high … In hepatocellular carcinoma, targeted inhibition of STAT3 can prevent the …

[HTML][HTML] Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

VS Peche, TA Pietka, M Jacome-Sosa… - Nature …, 2023 - nature.com
… Suppression of sEV formation in mice reduces muscle FA … vivo inhibition of Src by Scr
inhibitor-1 on alkyne PA uptake. … (loxP/stop/loxP) with Cdh5-Cre(ERT2) mice 104 to generate …

[HTML][HTML] Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?

MM Stefanowicz-Rutkowska, W Matuszewski… - Open Life …, 2021 - degruyter.com
… of diabetic kidney disease (DKD) in patients with diabetes … PP1-mediated inhibition of the
Src kinase reduced fibrosis in … In an animal model with mice, it was shown that T3 increases …

[HTML][HTML] Recent insights into SREBP as a direct mediator of kidney fibrosis via lipid-independent pathways

D Dorotea, D Koya, H Ha - Frontiers in Pharmacology, 2020 - frontiersin.org
… -terminal domain containing the transactivation domain, a region … A mechanistic study
with primary rat mesangial cells (MCs) … SREBP1 inhibition by fatostatin prevented Ang II-induced …