Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review

P Alugoju, VKD Krishna Swamy… - Critical Reviews in …, 2023 - Taylor & Francis
… tubular epithelial cells (PTECs) in diabetic nephropathy. … High glucose exposure to
mesangial cells acts as a good in … to prevent high glucose-induced renal fibrosis in mesangial

The emerging role of HDACs: pathology and therapeutic targets in diabetes mellitus

S Dewanjee, J Vallamkondu, RS Kalra, P Chakraborty… - Cells, 2021 - mdpi.com
… function in renal mesangial cells in diabetic kidneys [223]. … represents a therapeutic option
in diabetic nephropathy [65]. … found to prevent high glucose-induced myocardial damage …

A network pharmacology strategy to investigate the anti-osteoarthritis mechanism of main lignans components of Schisandrae Fructus

L Min, Y Wu, G Cao, D Mi, C Chen - International Immunopharmacology, 2021 - Elsevier
… MMP 13 and collagen II by affecting the SRC-EGFR-MAPK14 … on SRC gene expression in
the right knee cartilage of mice. (K) … inhibit the expression and activity of SRC to inhibit EGFR

Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney

MM Stefanowicz-Rutkowska, W Matuszewski… - degruyter.com
… of diabetic kidney disease (DKD) in patients with diabetes mellitus … Inhibition of Src kinase
blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells

γ peptide nucleic acid-based miR-122 inhibition rescues vascular endothelial dysfunction in mice fed a high-fat diet

RR Gaddam, K Dhuri, YR Kim, JS Jacobs… - Journal of medicinal …, 2022 - ACS Publications
… that the inhibition of miR-122 prevents … The high glucose condition decreases eNOS
activation. (69,70) Our results show that miR-122 inhibition partially rescues a high-glucose-induced

ADAM 17 and epithelial-to-mesenchymal transition: the evolving story and its link to fibrosis and cancer

M Sisto, D Ribatti, S Lisi - Journal of Clinical Medicine, 2021 - mdpi.com
High glucose (HG) is the base of diabetic nephropathy by determining ECM production in
glomerular mesangial cells… in the transactivation of Notch signalling in liver cancer stem cells, …

Augmented pulmonary vasoconstrictor reactivity after chronic hypoxia requires Src kinase and epidermal growth factor receptor signaling

CE Norton, JR Sheak, S Yan… - … of respiratory cell and …, 2020 - atsjournals.org
… We confirmed that Src kinase and EGFR inhibition did not alter … stretch-induced NOX activation
in mesangial cells (13). … EGFR is transactivated by a variety of stimuli, including platelet-…

G Protein-coupled receptor kinase 2 as novel therapeutic target in fibrotic diseases

N Li, S Shan, XQ Li, TT Chen, M Qi, SN Zhang… - Frontiers in …, 2022 - frontiersin.org
… of the liver fibrosis or in high glucose-induced CF (51, 52). … GRK2 activity is essential to
the transactivation of CXCR4 … the proliferation of glomerular mesangial cells, leading to the …

The function of KDEL receptors as UPR genes in disease

ES Wires, KA Trychta, LM Kennedy… - International journal of …, 2021 - mdpi.com
… UPR, cells were treated with an IRE1α kinase inhibitor that … of XBP1 in the mouse substantia
nigra pars compacta was … Src family kinases, in turn, play a role in EGFR transactivation

Pathogenesis of Microvascular Complications

M Khamaisi, GL King, K Park, Q Li - Diabetes Complications …, 2020 - Springer
… may contribute to diabetic nephropathy and retinopathy. Cultured rat mesangial cells (MC)
incubated with high glucose in the … Inhibition of Src kinase blocks high glucose-induced EGFR