Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast …
Abstract Treatment of breast cancer by paclitaxel (PAX) often encounters therapeutic failure
most likely caused by innate/acquired resistance. Cancer stem cells (CSCs) and multidrug
resistance complex (MDR-1 or P-glycoprotein) overexpression are main mechanisms
implicated in chemoresistance. Increased aldehyde dehrogenase-1 (ALDH-1) was
previously correlated with the stemness features of CSCs and hence is used as a marker for
identification and CSCs targeting. The present study, therefore, aimed at investigating the …
most likely caused by innate/acquired resistance. Cancer stem cells (CSCs) and multidrug
resistance complex (MDR-1 or P-glycoprotein) overexpression are main mechanisms
implicated in chemoresistance. Increased aldehyde dehrogenase-1 (ALDH-1) was
previously correlated with the stemness features of CSCs and hence is used as a marker for
identification and CSCs targeting. The present study, therefore, aimed at investigating the …
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