… HDAC6 inhibition leads to Hsp90 acetylation and disruption of its key chaperone functions.
… As mentioned above, HDAC6 can acetylate Hsp90 and affect the stability of its client proteins. …

… reversibly regulate the level of acetylation of Hsp90, thus disrupting its chaperone function
[29, 91… The oral histone deacetylase inhibitor LBH589 is a potential and promising therapeutic …

… of histones, HDAC6 is responsible for the deacetylation and … leads to the accumulation of
acetylated Hsp90, which is not … or HDAC6 inhibitors with the first-in-class Hsp90 inhibitor 17-…

… as well as of the disrupted association between the mitochondria … to promote chaperone
activity through HSF (Heat Shock Factor) for … Cortactin is in the acetylated state and needs to be …

… Histone deacetylase 6 (HDAC6) has been shown to control … -regulated α-syn oligomers in a
heat shock protein 90 (Hsp90)-… 71.7 %, and increased the acetylated α-tubulin levels by 86.3 …

… (C) HSP90 under basal conditions forms a complex with HDAC6 and heat-shock transcription
… The use of HDAC6 inhibitors in a cellular model of HD increased acetylated tubulin and …

… This study demonstrated that histone deacetylase (HDAC) inhibitors enable the heat shock
… Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat …

… HDAC6 regulation, which involves disrupting the HDAC6 and heat shock protein 90 (HSP90) …
induced by heat shock is mainly regulated by HDAC6 Histone acetylation modifications are …

… Histone deacetylase (HDACs) inhibitors commonly lead to … of polypeptide chains with
acetylated lysine side chains. The … increases acetylation of the HSP90 chaperone and disrupts …

… Histone deacetylase 6 (HDAC6) is proposed to be the major deacetylase of HSP90, however,
available data about … Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the …