Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism
YQ Song, Q Jin, DD Wang, J Hou, LW Zou… - Chemico-Biological …, 2021 - Elsevier
… in discovery of hCES inhibitors from clinically available … Three comprehensive lists of hCES
inhibitors deriving from … , alongside with their inhibition potentials and inhibition parameters, …
inhibitors deriving from … , alongside with their inhibition potentials and inhibition parameters, …
[HTML][HTML] Can We Improve Diosmetin Activity? The State-of-the-Art and Promising Research Directions
M Wujec, M Feldo - Molecules, 2023 - mdpi.com
… The phosphorylated flavonoids were tested for the inhibition of carboxylesterases [32]. This
is a family of enzymes … Some of these phosphorylated flavonoids were identified as potent …
is a family of enzymes … Some of these phosphorylated flavonoids were identified as potent …
Recent developments of flavonoids with various activities
ZG Sun, ZN Li, JM Zhang, XY Hou… - Current Topics in …, 2022 - ingentaconnect.com
… Compound 3 (IC50 㸺 50 ȣM) displayed the most potent inhibition … potent telomerase inhibitors
derived from flavonoids [23]. … develop more effective flavonoidtype hCE2 inhibitors [152]. …
derived from flavonoids [23]. … develop more effective flavonoidtype hCE2 inhibitors [152]. …
Efficient Synthesis of Phosphorus/Nitrogen‐Containing Chrysin Derivatives via Classic Reactions
Z Zeng, S Liu, W Luo, J Liang, AY Peng - ChemistrySelect, 2021 - Wiley Online Library
… phosphorylated flavonoids and identified 7-phosphorylated chrysin as the most effective
and selective inhibitor of … esterase (CEase) and porcine liver carboxylesterase (CE) with low …
and selective inhibitor of … esterase (CEase) and porcine liver carboxylesterase (CE) with low …
[HTML][HTML] Approaches to measuring the activity of major lipolytic and lipogenic enzymes in vitro and ex vivo
M Wilhelm, L Rossmeislová, M Šiklová - International Journal of …, 2022 - mdpi.com
… In mouse AT, phosphorylation of these serine residues is … [42]), carboxylesterase 1 and
even FA synthase (FAS) [43]. … as phenolics (catechnins, flavonoids, tannins, stilbenes) and …
even FA synthase (FAS) [43]. … as phenolics (catechnins, flavonoids, tannins, stilbenes) and …
[HTML][HTML] A molecular insight into the role of antioxidants in nonalcoholic fatty liver diseases
D Ezhilarasan, T Lakshmi - Oxidative Medicine and Cellular …, 2022 - hindawi.com
… in βoxidation and oxidative phosphorylation in mitochondria, … of the Nrf2/carboxylesterase 1
signaling pathway involved in the … This study suggests that flavonoid compounds can induce …
signaling pathway involved in the … This study suggests that flavonoid compounds can induce …
Pharmacological review of isobavachalcone, a naturally occurring chalcone
… Gu Zhi include coumarins, flavonoids, meroterpenes, benzofuran… IBC bonded the active
pocket of carboxylesterase 1 (CES1), … of STAT6 phosphorylation and subsequent inhibition of the …
pocket of carboxylesterase 1 (CES1), … of STAT6 phosphorylation and subsequent inhibition of the …
Porcine cytochrome P450 3A: current status on expression and regulation
MK Rasmussen - Archives of Toxicology, 2020 - Springer
… alternative splicing, posttranslational modification like phosphorylation, and epigenetic control
via … , the mode of inhibition was determined as competitive. Other major flavonoids such as …
via … , the mode of inhibition was determined as competitive. Other major flavonoids such as …
[HTML][HTML] Toxic mechanism and biological detoxification of fumonisins
L Qu, L Wang, H Ji, Y Fang, P Lei, X Zhang, L Jin… - Toxins, 2022 - mdpi.com
… 2+ , resulting in JNK phosphorylation, activation of the p53 apoptosis … flavonoids and fenac,
and has antioxidant activities. … under the action of carboxylesterase to form hydrolyzed FB 1 (…
and has antioxidant activities. … under the action of carboxylesterase to form hydrolyzed FB 1 (…
An Insight into the Potential of Flavonoids and Furanocoumarins in the Treatment of Psoriasis
A Singh, N Srivastava - Current Bioactive Compounds, 2023 - ingentaconnect.com
… majus L., decreased isolated mitochondria's ability to respire and phosphorylate when …
efficient NADPH oxidase inhibitors. It is possible that flavonoids that inhibit NADPH oxidase affect …
efficient NADPH oxidase inhibitors. It is possible that flavonoids that inhibit NADPH oxidase affect …