How changes in dopamine D2 receptor levels alter striatal circuit function and motivation

EH Simpson, EF Gallo, PD Balsam, JA Javitch… - Molecular …, 2022 - nature.com
… versus dorsal striatum further defined the striatal subregion(s… Local injection of the D2R
agonist bromocriptine into the NAc … and not value-based decisions: Here we focused mainly on …

[HTML][HTML] … dopamine type 2 gene expression in the dorsal striatum in individuals with autism spectrum disorder suggests alterations in indirect pathway signaling and …

C Brandenburg, JJ Soghomonian, K Zhang… - Frontiers in Cellular …, 2020 - frontiersin.org
disruption of neurochemical modulation via dopamine within GABAergic MSNs in the
dorsal striatum … in a key regulator of action selection may be relevant for motor dysfunction, …

Double dissociation between actions of dopamine D1 and D2 receptors of the ventral and dorsolateral striatum to produce reinstatement of cocaine seeking behavior

RC Campos, C Dias, F Darlot, M Cador - Neuropharmacology, 2020 - Elsevier
… the injection needles, the DA receptor agonists or antagonists at different … between the ventral
and dorsal striatum may thus have … of receptor mediation and behavioral disruption in rats …

Emerging roles of striatal dopamine D2 receptors in motivated behaviour: Implications for psychiatric disorders

PR Olivetti, PD Balsam, EH Simpson… - Basic & clinical …, 2020 - Wiley Online Library
… , specific treatment options for motivational deficits remain … Cre‐dependent form of Drd2 was
injected into the NAc of adult D2‐… to dopamine compared to D2‐MSNs in the dorsal striatum. …

D2/3 agonist during learning potentiates cued risky choice

L Mortazavi, TJ Hynes, CS Chernoff… - Journal of …, 2023 - Soc Neuroscience
… that dopamine agonists should boost risky choice through … , IL, and PrL), striatal regions
(NAcc and dorsal striatum), and … cocaine injections and decrease the sensitivity of striatal D 2

Striatal dopamine integrates cost, benefit, and motivation

N Eshel, GC Touponse, AR Wang, AK Osterman… - Neuron, 2024 - cell.com
decisions, individuals must combine cost and benefit to determine whether the benefit is worth
the cost. This cost-benefit calculus is at … in both ventral and dorsal striatum (Figures 4F and …

The effects of the dopamine D2/3 agonist quinpirole on incentive value and palatability-based choice in a rodent model of attention-deficit/hyperactivity disorder

JY Natsheh, D Espinoza, S Bhimani, MW Shiflett - Psychopharmacology, 2021 - Springer
Dopamine signaling is disrupted in attention-deficit … Injections occurred after outcome
devaluation and 20 min … Food has robust reinforcing effects mediated by striatal dopamine

Dissociating the effects of dopamine D2 receptors on effort-based versus value-based decision making using a novel behavioral approach.

MR Bailey, E Chun, E Schipani, PD Balsam… - Behavioral …, 2020 - psycnet.apa.org
… the role of dopamine signaling via D2 receptors on effort-based choice, we injected mice with
… do not disrupt primary food motivation, that is, consumption behavior in conditions that do …

Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1-and D2-SPNs

P Bonnavion, C Varin, G Fakhfouri… - Nature …, 2024 - nature.com
… We have shown that the disruption of this pathway, which … selection cassette were inserted
at the ATG site of the D1 DA … µm above the injection site in the dorsal striatum. Following optic …

Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors

J Enriquez-Traba, HE Yarur-Castillo, RJ Flores, T Weil… - bioRxiv, 2023 - biorxiv.org
… by injecting Cre-expressing virus (AAV8-hSyn-GFP-Cre) into … to run, we designed a choice
task wherein mice were allowed … striatum are longer-lasting relative to the dorsal striatum 95 . …