[HTML][HTML] Adipose tissue: physiology to metabolic dysfunction

AJ Richard, U White, CM Elks, JM Stephens - Endotext [internet], 2020 - ncbi.nlm.nih.gov
Skeletal muscle is responsible for up to 80% of insulin-mediated glucose uptake in healthy
… mice, and conversely, resistin injection impairs glucose tolerance in normal mice; supporting …

Obesity and insulin resistance: pathophysiology guiding precision therapy

A Basu, R Basu - Insulin, 2023 - Elsevier
glucose uptake, primarily in the skeletal muscle, and to … (free) fatty acids (NEFA) from
adipose tissue depots, and … splanchnic tissues to insulin-mediated suppression of lipolysis. …

The importance of intramuscular triglyceride turnover on skeletal muscle insulin sensitvity

J Barrett - 2023 - researchonline.ljmu.ac.uk
… via lipolytic inhibition leads to reduced ceramide 20:0 … insulin-mediated suppression of
HSL, and therefore adipose … -adipose tissues such as the liver and skeletal muscle in both …

Expansion and impaired mitochondrial efficiency of deep subcutaneous adipose tissue in recent-onset type 2 diabetes

K Bódis, T Jelenik, J Lundbom… - The Journal of …, 2020 - academic.oup.com
… relation to tissue-specific insulin sensitivity of the skeletal muscle, … patients with T2D and 14
men with normal glucose tolerance (… Lower insulin-mediated suppression of lipolysis reflects …

Exploring the role of skeletal muscle in insulin resistance: lessons from cultured cells to animal models

A Feraco, S Gorini, A Armani, E Camajani… - International Journal of …, 2021 - mdpi.com
… 75% of all insulin-mediated glucose disposal. Alterations of … skeletal muscle communicates
with adipose tissue to induce … LPL in skeletal muscle show impaired glucose tolerance with …

Insulin, muscle glucose uptake, and hexokinase: revisiting the road not taken

DH Wasserman - Physiology, 2022 - journals.physiology.org
… insulin stimulates glucose transport across the skeletal muscle cell … -resistant mouse model
improves glucose tolerance (118). … action on glucose transport in the isolated rat adipose cell. …

Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans

D Kahn, L Perreault, E Macias, S Zarini, SA Newsom… - Diabetologia, 2021 - Springer
… Excess accumulation of IMTG in skeletal muscle is … extramuscular adipose tissue and then
45–60 mg of frozen muscle was … of the individuals with obesity had normal glucose tolerance. …

Metabolic effects of alternate-day fasting in males with obesity with or without type 2 diabetes

A Ingersen, HR Helset, M Calov, E Chabanova… - Frontiers in …, 2022 - frontiersin.org
… would decrease adipose tissue mass and liver fat content. … intravenous glucose tolerance
test (IVGTT) in patients with obesity (… on insulin-mediated glucose uptake in skeletal muscle in …

Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion

X Han, SH Raun, M Carlsson, KA Sjøberg… - Metabolism, 2020 - Elsevier
glucose intolerance that was restored by blockage of whole-body fatty acid oxidation or adipose
tissue lipolysis. … -stimulated glucose uptake in both skeletal muscle and adipose tissue in …

Cellular and Molecular Mechanisms of Insulin Resistance

P Chandrasekaran, R Weiskirchen - Current Tissue Microenvironment …, 2024 - Springer
… , skeletal muscle, and adipose tissue by suppressing hepatic … increases insulin-mediated
glucose uptake in skeletal muscle, … lipid accumulation and improves glucose tolerance [42, 43]. …