Classic metabolic actions of insulin in humans: from physiology to disease and novel pharmacotherapeutics
AJ Krentz - Insulin, 2023 - Elsevier
… in states of normal glucose tolerance and normal insulin … tissues, that is, the liver, skeletal
muscle, and adipose tissue (… meal, insulin-mediated inhibition of adipocyte lipolysis leads to …
muscle, and adipose tissue (… meal, insulin-mediated inhibition of adipocyte lipolysis leads to …
… cardiac dietary fatty acid partitioning and hepatic insulin resistance through increased intra-abdominal adipose tissue storage and reduced spillover in type 2 diabetes
AM Carreau, C Noll, DP Blondin, F Frisch… - Diabetes, 2020 - Am Diabetes Assoc
… that individuals with impaired glucose tolerance have decreased … and Ra NEFA from adipose
tissue intracellular lipolysis were … , increased insulin-mediated cardiac glucose uptake, and …
tissue intracellular lipolysis were … , increased insulin-mediated cardiac glucose uptake, and …
Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance
SM Frangos, DJ Bishop, GP Holloway - Biochemical Journal, 2021 - portlandpress.com
… as white adipose tissue (WAT), liver, and skeletal muscle), … ); a required event for
insulin-mediated phosphorylation of Rab-… contribute to whole-body glucose intolerance seen with …
insulin-mediated phosphorylation of Rab-… contribute to whole-body glucose intolerance seen with …
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
M Li, X Chi, Y Wang, S Setrerrahmane… - Signal transduction and …, 2022 - nature.com
… mediators released by adipose tissue including adipokines, … uptake from blood into liver,
fat, and skeletal muscle cells. … in suppression of lipolysis in adipocytes by inhibiting adipose …
fat, and skeletal muscle cells. … in suppression of lipolysis in adipocytes by inhibiting adipose …
[PDF][PDF] Dissociation of muscle insulin resistance from alterations in mitochondrial substrate preference
… Similar to what we observed in the rat skeletal muscle, the … and prevent insulin-mediated
muscle glucose uptake by a … oral glucose-tolerance test to assure normal glucose tolerance …
muscle glucose uptake by a … oral glucose-tolerance test to assure normal glucose tolerance …
Adipose tissue inflammation is directly linked to obesity-induced insulin resistance, while gut dysbiosis and mitochondrial dysfunction are not required
… metabolic changes in skeletal muscle, adipose tissue, liver, the … and glucose intolerance
are closely linked with obesity in … adipose tissue impairs insulin-mediated suppression of …
are closely linked with obesity in … adipose tissue impairs insulin-mediated suppression of …
[HTML][HTML] The crucial role of muscle glucocorticoid signaling in accelerating obesity and glucose intolerance via hyperinsulinemia
H Yamazaki, M Uehara, N Yoshikawa… - JCI insight, 2023 - ncbi.nlm.nih.gov
… In this study, we first show that fat accumulation in adipose tissue or liver… muscle GR–originated
and insulin-mediated metabolic communication involving WAT, liver, and skeletal muscle…
and insulin-mediated metabolic communication involving WAT, liver, and skeletal muscle…
The effects of growth hormone on adipose tissue: old observations, new mechanisms
… in skeletal muscle and decreased glucose tolerance 10,11,12… uptake and oxidation in
skeletal muscle in vivo. Moreover, … and 3 adipocytes display increased insulin-mediated glucose …
skeletal muscle in vivo. Moreover, … and 3 adipocytes display increased insulin-mediated glucose …
The role of hepatic fat accumulation in glucose and insulin homeostasis—dysregulation by the liver
A London, AM Lundsgaard, B Kiens… - Journal of Clinical …, 2021 - mdpi.com
… to impaired insulin-mediated suppression of hepatic glucose … studies aiming at evaluating
skeletal muscle insulin sensitivity [… muscle and adipose tissue, is central in the pathogenesis of …
skeletal muscle insulin sensitivity [… muscle and adipose tissue, is central in the pathogenesis of …
Whole-body insulin resistance and energy expenditure indices, serum lipids, and skeletal muscle metabolome in a state of lipoprotein lipase overexpression
Y Nishida, K Nishijima, Y Yamada, H Tanaka… - Metabolomics, 2021 - Springer
… that obesity and insulin resistance or type 2 diabetes are … of free fatty acid during the
intravenous glucose tolerance test … and tissue sites of non-insulin- and insulin-mediated glucose …
intravenous glucose tolerance test … and tissue sites of non-insulin- and insulin-mediated glucose …