Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo …
M Jamei, B Abrahamsson, J Brown, J Bevernage… - European Journal of …, 2020 - Elsevier
… intrinsic parameters are determined those can be incorporated within PBPK models that
facilitate the integration of the drug API/formulation data consisting of the relevant …
facilitate the integration of the drug API/formulation data consisting of the relevant …
Recent progressions in biomedical and pharmaceutical applications of chitosan nanoparticles: A comprehensive review
EM Khalaf, NA Abood, RZ Atta… - International Journal of …, 2023 - Elsevier
… These nanofibers which can be tailored and textile in a form of an integrated patch and
introduced to the wound healing market, are fabricated in a size less than 100 nm in diameter […
introduced to the wound healing market, are fabricated in a size less than 100 nm in diameter […
[HTML][HTML] Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges
KP Das - Frontiers in Medical Technology, 2023 - frontiersin.org
… complex data and facilitating during drug discovery and drug design, respectively. In addition,
this form of AI integration allows for addressing the limitations with accurate dose delivery. …
this form of AI integration allows for addressing the limitations with accurate dose delivery. …
Application of deep neural network models in drug discovery programs
C Grebner, H Matter, D Kofink, J Wenzel… - …, 2021 - Wiley Online Library
… -integration into our model-building pipeline. All DNN models discussed in this work are
integrated in … chemistry towards a more realistic picture of artificial intelligence in drug discovery. …
integrated in … chemistry towards a more realistic picture of artificial intelligence in drug discovery. …
[HTML][HTML] The evolving role of investigative toxicology in the pharmaceutical industry
F Pognan, M Beilmann, H Boonen, A Czich… - … reviews drug discovery, 2023 - nature.com
… There are a vast number of new platform technologies, and a comprehensive description
of all of them is beyond the scope of this article. However, through a survey of 14 Europe-based …
of all of them is beyond the scope of this article. However, through a survey of 14 Europe-based …
Data-independent acquisition (DIA): an emerging proteomics technology for analysis of drug-metabolizing enzymes and transporters
… as precision medicine, biomarker discovery, and drug screening. … Using a publicly available
comprehensive organism-level … with a higher risk of false discovery. Thus, a DIA study was …
comprehensive organism-level … with a higher risk of false discovery. Thus, a DIA study was …
Application of machine learning in translational medicine: current status and future opportunities
N Terranova, K Venkatakrishnan, LJ Benincosa - The AAPS Journal, 2021 - Springer
… of ML applications in drug discovery and development, aligned with … drug development
(10). Together with the automation of process pipelines and operational design, the integration …
(10). Together with the automation of process pipelines and operational design, the integration …
Natural bioactive products as promising therapeutics: A review of natural product-based drug development
CB Aware, DN Patil, SS Suryawanshi, PR Mali… - South African Journal of …, 2022 - Elsevier
… The inadequacy in pharmacological evaluation, preclinical and clinical examination of
herbal drugs impedes their integration into contemporary medicinal practices. The preclinical …
herbal drugs impedes their integration into contemporary medicinal practices. The preclinical …
[HTML][HTML] PET molecular imaging in drug development: the imaging and chemistry perspective
… advances the drug discovery and development process at the … mechanism, pharmacokinetic
and pharmacodynamic profiles. … therapeutic drug development, doses regimen, and drug …
and pharmacodynamic profiles. … therapeutic drug development, doses regimen, and drug …
Driving success in personalized medicine through AI-enabled computational modeling
… preclinical and clinical systems biology ‘big-data’, an innovative approach deploying AI-integrated
mechanistic models to drug development has markedly increased the predictability of …
mechanistic models to drug development has markedly increased the predictability of …