… In recent years, commercially available OoCs have been increasingly integrated within
the drug development phase, to replace more traditional preclinical models (Figure 2; [3–6]). …

… drug development, focusing largely on drug–drug interactions (DDIs), but also including other
topics relevant to the role of transporters in drug … The integration of time-resolved imaging …

… processes is an essential part of drug discovery and development. In recent years, artificial
… Overall, we provided a comprehensive overview of recent AI-based drug metabolism and …

… In this review, the possible mechanisms and pharmacokinetic and pharmacodynamic effects
of some pharmacological agents used in treating COVID-19 or alleviating its symptoms are …

… into the drug discovery and development pipeline. Key learning objectives will include how
to minimize the disruption these technologies cause and how to integrate them with current …

… Drug development suffers from a lack of predictive and … In addition, we integrate electrical
sensors, demonstrating … and oxygen consumption via integrated oxygen sensors. Finally, we …

… ) drug development yet difficult due to ethical restrictions of human brain sampling. CNS
pharmacokinetic (PK… We previously published a comprehensive CNS physiologically-based PK (…

… drug development community and offered a call to action for reforming current approaches.
… integrated in a mechanism- informed manner through modeling and simulation. Prior knowl- …

… the entire process of drug development with an emphasis on … we believe that such a
comprehensive summary of this subject … drug development system, ie, from drug synthesis to drug …

… Among alkaloids, isoquinoline alkaloids are known as natural plant products that have
demonstrated a considerable impact in drug discovery. Isoquinoline alkaloids are predominantly …