… , in pancreatic cancer (eg pancreatic ductal adenocarcinoma, … This review synthesizes
current knowledge on important … is induced in response to Gemcitabine treatment through the …

… an essential factor in this failure. This review analyzes the molecular causes of gemcitabine
resistance … at decreasing, delaying or even reversing chemoresistance in pancreatic cancer. …

… Differential integrated stress response and 793 asparagine production drive … Integrated
stress response is critical for 863 gemcitabine resistance in pancreatic ductal adenocarcinoma. …

… molecular mechanisms that play a crucial role in PDAC therapy resistance and how a better
… therapy response in pancreatic tumors. Acquired gemcitabine-resistant models of pancreatic …

… Chemotherapy regimens, including gemcitabine used in … hypoxia in human pancreatic
ductal adenocarcinoma (PDAC… plays a crucial function in the cellular stress response by …

… , of patients with pancreatic ductal adenocarcinoma (PDAC) die … and hCNT3 are crucial
mediators of gemcitabine uptake in PC … to increased glycolysis and gemcitabine resistance [176]. …

… In this paper, we take gemcitabine resistance as an example because relatively less research
has been … Therefore, hNTs play a crucial role in determining sensitivity and resistance to …

… play important roles in tumour proliferation, invasiveness, and metastasis and resistance
to … with untreated metastatic pancreatic adenocarcinoma 29 Lapatinib and gemcitabine (25); …

… in the stress response, increased apoptosis of pancreatic β cells and, consequently, to type
I diabetes … are some suggestions that ER stress may contribute to gemcitabine resistance. In …

… , we critically review the role of the various stromal components in determining resistance
to … In PDAC, CD36 is able to influence gemcitabine resistance through the regulation of anti-…