… should be integrated into biopredictive dissolution testing (low … poor aqueous solubility
and high permeability, these dynamic … The obtained underlying cumulative dissolution profile …

… validation, the virtual dissolution profiles were integrated into … and pharmaceutical scientists
to use mechanistic IVIVC’s for … systems such as dissolution/permeation (eg PermeaLoop™), …

… with design of experiment (DoE) that integrates the DoE into … vitro dissolution and in vivo
drug concentrations, IVIVC allows … IVIVC methods has been limited to highly permeable drugs, …

… integrated dissolution–absorption models, the dissolution/… dissolved drugs and cause less
disturbance in drug permeation. … very difficult to establish IVIVC for drugs especially exhibiting …

… , integration of modeling and simulation with current IVIVC … III drugs may be eligible with an
IVIVC and high dissolution rates, … unpredictability of both low solubility and permeability [12]. …

… of product development, it is necessary an integrated work of … on different drugs regarding
the application of IVIVC, and it … condition for dissolution and, consequently, permeability. Sub-…

… (IVIVC) and clinically relevant dissolution specifications (CRDS) … to integrate dissolution data
(ie, virtual dissolution profiles … a BCS III molecule with permeability controlled absorption [27…

… drug dissolution in terms of physiological time constraints. Intuitively, in vivo drug dissolution
runs for a finite dissolution … the in vivo drug absorption, eg, permeability or stability issues. …

… As a result, for poorly permeable drugs, conventional IVIVCs … to establish IVIVC, it is often
challenging to define the IVIVC’s … be appropriate to integrate the in vitro dissolution data into …

… development and drug characterization, dissolution testing is … However, drug classification
based on solubility and permeability … The concept of IVIVC development is schematically …