… that gene expression of HFE, transferrin receptor 1 (TfRC) and transferrin receptor 2 (TfR2)
on … loaded transferrin for the binding to the transferrin receptor, but it does not just interact with …

… HFE. Studies directed instead to examining the functional consequences of this interaction
on HFE … by which the interaction of HFE with TFR1 prevents HFE from otherwise exerting an …

… binding of the transferrin protein (TF) with the Transferrin Receptor 1 (TFR1) protein (responsible …
The TF-TFR1 binding displaces the HFE protein that then is free to interact with TFR2 to …

… The hepatocytes also express transferrin receptor 2 (TFR2); however, its affinity for … highly
saturated transferrin stabilizes TfR2, disrupting the interaction between the HFE protein and …

… that the hemochromatosis proteins [HFE, transferrin receptor 2 (TFR2) … Patients affected by
hemochromatosis type-1, -2, -3 have a … interactions with diferric transferrin (Tf-Fe2), transferrin …

… HFE interacts with transferrin receptor 2 (TFR2), leading to increased stabilization and activation
of bone morphogenic protein … interaction of the iron-transferrin complex with its receptor, …

… affinity when compared to the HFE-TfR1 interaction 20 20 Delima RD, Chua ACG, Tirnitz-Parker
JEE, et al. Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-…

… Transferrin receptor 2 (TFR2) resembles TFR1 and can also bind iron-loaded transferrin …
case of excess iron and high transferrin saturation will result in a TFR2-HFE interaction. This …

… A second transferrin receptor—TFR2—associates with the erythropoietin receptor and has
been implicated in the regulation of erythropoiesis. In erythroblasts, both transferrin receptors …

… HFE is a component of an iron-sensing complex interacting with diferric transferrin (Tf-Fe 2
) and transferrin receptors (… Tf-Fe 2 displaces HFE from TFR1, which then links to TFR2 and …