The anti-VEGF (R) drug discovery legacy: improving attrition rates by breaking the vicious cycle of angiogenesis in cancer

D Ribatti, AG Solimando, F Pezzella - Cancers, 2021 - mdpi.com
… , VEGF production is related to vasodilation; VEGFR-2 is also related to cell survival and
migration, and VEGFR-1 is … soluble neuropilin-1 (sNRP-1), which is a co-receptor for VEGF in …

[PDF][PDF] Temporal Vascular Endothelial Growth Factor Sub-type gene Switching in SARS-CoV Pathogenesis. Interpretation through in vivo Murine C57BL Models

A Rashid, ZA Malik, V Sharma, A Sharma, L Gupta… - 2022 - researchgate.net
… that VEGF-A and VEGF-B share the receptor VEGFR-1, we … CoV-2 spike protein can co-op
the VEGF-A/neuropilin-1 … rise in VEGF-A results in angiogenesis from VEGFR-2 stimulation. …

Peripheral vascular disease: preclinical models and emerging therapeutic targeting of the vascular endothelial growth factor ligand-receptor system

VC Ganta, BH Annex - Expert opinion on therapeutic targets, 2021 - Taylor & Francis
isoforms, and the pathways altered by modulating different VEGF receptor-ligand interactions,
… including in vitro or ex vivo macrophage conditioned medium or human plasma samples …

[HTML][HTML] A multiscale computational model of angiogenesis after traumatic brain injury, investigating the role location plays in volumetric recovery

A Baird, L Oelsner, C Fisher, M Witte… - Mathematical …, 2021 - aimspress.com
VEGF is of particular interest after a traumatic brain injury (TBI), as it re-… a computational
model that quickly simulates vessel growth and recovery by coupling VEGF and its interactions

Regulation of cells of the arterial wall by hypoxia and its role in the development of atherosclerosis

S Norda, R Papadantonaki - Vasa, 2022 - econtent.hogrefe.com
… -4) and neuropilins (NRPs) acting as VEGF co-receptors [119]. … VEGFR-1 embodies a tyrosine
kinase with decreased activity due to its function as decoy receptor antagonizing VEGFR-2

Temporal Vascular Endothelial Growth Factor Sub-type Gene Switching in SARS-CoV-related Inflammation-Basis for a Dual Gene Biomarker Approach

A Rashid, G Benakati, F Al-Obeidat, ZA Malik, J Brierley… - bioRxiv, 2022 - biorxiv.org
… that VEGF-A and VEGF-B share the receptor VEGFR-1, we … CoV-2 spike protein can co-op
the VEGF-A/neuropilin-1 … rise in VEGF-A results in angiogenesis from VEGFR-2 stimulation. …

[HTML][HTML] Systems biology will direct vascular-targeted therapy for obesity

Y Fang, T Kaszuba, PI Imoukhuede - Frontiers in Physiology, 2020 - frontiersin.org
… requires appropriate computational models and quantitative … A recent study of VEGF-A
(xxx)b mRNA in vivo further … healthy mouse skeletal muscle and tumor xenograft models, where …

Affinity-enhanced multimeric VEGF (vascular endothelial growth factor) and PlGF (placental growth factor) variants for specific adsorption of sFlt-1 to restore …

M Matin, M Mörgelin, J Stetefeld, B Schermer… - …, 2020 - Am Heart Assoc
… affinity for sFlt-1 in the absence of heparin or neuropilin 1. … VEGF isoform VEGF 95 only
displays reduced interaction with … We introduce the first in vivo applicable apheresis system for …

Neuropilin-2 as a Novel Angiogenic Player: deciphering the contributions of neuropilin-2 during developmental and pathological angiogenesis

C Benwell - 2022 - ueaeprints.uea.ac.uk
… depletion in vitro, … interacting with high affinity to two transmembrane bound cell surface
receptor families; the VEGFR family of tyrosine kinase receptors, notably VEGFR-1 and VEGFR-2

Angiogenesis in hepatocellular carcinoma; pathophysiology, targeted therapy, and role of imaging

AW Moawad, J Szklaruk, C Lall, KJ Blair… - Journal of …, 2020 - Taylor & Francis
… with complex but balanced interactions between pro-angiogenic … Membrane bound factors
include neuropilin receptors (NRP)… of these receptors: VEGFR-1, VEGFR-2, and VEGFR-3. …