… to co-receptors called neuropilin-1 and neuropilin-2 (NRP1, … A computational study showed
that VEGFR heterodimers are … to VEGF-A indicates that homotypic interactions between …

… a computational model describing the expression, interaction… (HSPGs) and Neuropilin-1
(NRP1); these isoform-selective co… to simulate endothelial cells in human in vivo models [33]. To …

… VEGFR-2 signaling [40,52,53,54]. Also, VEGFR-1 acts as a decoy for VEGF [55]. VEGFR2
is the primary molecule that … Neuropilins (NRP) are pleiotropic receptors that interact with …

… into the active sites of VEGFR-1-D2 and VEGFR-2-D2, … 2 was detected for the interaction
with VEGFR-2. This result is … was used for computational biomolecular interaction studies (…

… VEGF-A even interacts with the co-receptors like neuropillin … major receptors of VEGF-A
are VEGFR-1 and VEGFR-2 only, … , in vivo and in vitro studies to propose a better anti-VEGFR-2 …

… efficacy as well as structural binding and computational … domain, specifically for interaction
with VEGF ligands. The … Additionally, the activation of both VEGFR-1 and VEGFR-2 in …

… of VEGFR-1 has higher affinity for VEGF than VEGFR-2, and … in in vivo models, most of what
we know about VEGFR-2 … how VEGFR-2 acts as a mechanoreceptor and closely interacts …

… the membrane receptors VEGFR-1 and VEGFR-2, which are … Thus, VEGFR-1 has the capacity
to interact with other signal-… [6] performed computational modelling and indicated order of …

… and interaction with other co-receptors such as neuropilins [… identify that VEGF-A binds to
both VEGFR-1 and VEGFR-2 in … like VEGF-A does, with evidence both in vivo and vitro [55, 58…

… ), FLT4 (coding for VEGFR-3) and Neuropilin-1 and -2 (NRP1/NRP2), … vivo, this effect is also
mediated in parallel by the VEGF/VEGFR-2 interaction, whereas VEGF that bind to VEGFR-1 …