Characterising the role of neuropilin-1 in claudin-low breast cancer

LR Lynam - 2023 - eprints.qut.edu.au
… In-vitro and In-vivo studies have implicated NRP1 in the regulation of EMT and tumour …
The interactions of NRP1 with semaphorins and vascular endothelial growth factors (VEGF) are …

Vascular endothelial growth factor receptors [VEGFR] as target in breast cancer treatment: current status in preclinical and clinical studies and future directions

M Malekan, MA Ebrahimzadeh - Current Topics in Medicinal …, 2022 - ingentaconnect.com
… that expressing both VEGFR-1 and VEGFR-2 in the cell lines … vascular development after
interaction with VEGFR-2 [31, 57]. … effects of wogonin in vitro and in vivo revealed that this agent …

Preparation, In Vitro Affinity, and In Vivo Biodistribution of Receptor-Specific 68Ga-Labeled Peptides Targeting Vascular Endothelial Growth Factor Receptors

P Barta, R Kamaraj, M Kucharova, Z Novy… - Bioconjugate …, 2022 - ACS Publications
… into the active sites of VEGFR-1-D2 and VEGFR-2-D2, … 2 was detected for the interaction
with VEGFR-2. This result is … was used for computational biomolecular interaction studies (…

[HTML][HTML] New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization

HAA Ezelarab, TFS Ali, SH Abbas, AM Sayed… - Molecular Diversity, 2024 - Springer
… three isoforms of VEGF receptors, namely VEGFR-1 (Flt-1), … the same binding interactions
inside the VEGFR-2’s binding … the furthermost practical computational approaches to offer a …

Affinity-enhanced multimeric VEGF (vascular endothelial growth factor) and PlGF (placental growth factor) variants for specific adsorption of sFlt-1 to restore …

M Matin, M Mörgelin, J Stetefeld, B Schermer… - …, 2020 - Am Heart Assoc
… high affinity for sFlt-1 in the absence of heparin or neuropilin 1. … VEGF isoform VEGF 95 only
displays reduced interaction with … 165 did not improve binding in contrast to computational

[PDF][PDF] Temporal Vascular Endothelial Growth Factor Sub-type gene Switching in SARS-CoV Pathogenesis. Interpretation through in vivo Murine C57BL Models

A Rashid, ZA Malik, V Sharma, A Sharma, L Gupta… - academia.edu
… that VEGF-A and VEGF-B share the receptor VEGFR-1, we … CoV-2 spike protein can co-op
the VEGF-A/neuropilin-1 … rise in VEGF-A results in angiogenesis from VEGFR-2 stimulation. …

[HTML][HTML] Aflibercept Off-Target Effects in Diabetic Macular Edema: An In Silico Modeling Approach

M Blanot, RP Casaroli-Marano… - International Journal of …, 2024 - mdpi.com
… We obtained computational models of the effect of IAI on … DME pathophysiological processes,
such as neuropilins (NRPs), … by VEGF-A, VEGF-B, PlGF, and Gal-1 by interacting with their …

Characterization of Novel Anti-VEGFR Antibodies to Develop Agonists Targeting Mesoderm Differentiation

S Mishra - 2021 - search.proquest.com
… Table 3: Summary of in vitro binding constants for the … but its activation indicates the interaction
of endothelial cells with … VEGFR-1 and VEGFR-2 agonists that can replace VEGF. Natural …

[HTML][HTML] Quinazolines and thiazolidine-2, 4-dions as SARS-CoV-2 inhibitors: repurposing, in silico molecular docking and dynamics simulation

SSA El-Hddad, MH Sobhy, A El-Morsy, NA Shoman… - RSC …, 2024 - pubs.rsc.org
VEGFR-1 (sFlt-1) activation appears to be as an endogenous VEGF inhibitor, while VEGFR-2
… On the other hand using VEGFA, a physiological ligand for the b1b2 pocket in neuropilin-1 …

[HTML][HTML] The anti-VEGF (R) drug discovery legacy: improving attrition rates by breaking the vicious cycle of angiogenesis in cancer

D Ribatti, AG Solimando, F Pezzella - Cancers, 2021 - mdpi.com
… , VEGF production is related to vasodilation; VEGFR-2 is also related to cell survival and
migration, and VEGFR-1 is … soluble neuropilin-1 (sNRP-1), which is a co-receptor for VEGF in …