Optimization of size of nanosensitizers for antitumor radiotherapy using mathematical modeling

M Kuznetsov, A Kolobov - International Journal of Molecular Sciences, 2023 - mdpi.com
… Moreover, apparently due to their computational complexity, … The block scheme of the main
model interactions is … the influence of vascular endothelial growth factor, VEGF. Glucose was …

[PDF][PDF] Cardiac Endothelial Cells: Potential Therapeutic Targets in Heart Disease

KA Hemanthakumar - 2021 - helda.helsinki.fi
… molecular mechanisms in in vivo and in vitro model systems. … form of VEGF-B186 at Arg-127
can also bind to Neuropilin 1 (… Future studies delineating the EC-CMC interaction in …

Alternative vascularization mechanisms in tumor resistance to therapy

D Belotti, D Pinessi, G Taraboletti - Cancers, 2021 - mdpi.com
… to identify and measure it in vivo [55]. Morphological examination of … The interaction between
ephrinB2 expressed by platelet-… after short treatment with the VEGFR-2 inhibitor vatalanib or …

[图书][B] Genesis, Pathophysiology and Management of Venous and Lymphatic Disorders

N Radhakrishnan - 2022 - books.google.com
… The above-mentioned study examined functional interactions … with cell migration such as
neuropilin, restin, and midkine are … activity have high VEGFR-2 and low VEGFR-1 expression, …

Anti-angiogenic therapy in ovarian cancer: Current understandings and prospects of precision medicine

C Mei, W Gong, X Wang, Y Lv, Y Zhang… - Frontiers in …, 2023 - frontiersin.org
… of VEGFR-2 by VEGF-A (Zhao and Adjei, 2015). PIGF binds to VEGFR-1 and its co-receptors
neuropilin 1 (… Galectin-1 interacts with NRP-1, the co-receptor for VEGF, thereby activating …

[HTML][HTML] Angiogenesis in lymph nodes is a critical regulator of immune response and lymphoma growth

L Menzel, UE Höpken, A Rehm - Frontiers in Immunology, 2020 - frontiersin.org
… and propose probable cellular interactions that participate in … the VEGFR-1, providing a
strong rationale to target VEGF in … inhibition of the paracrine VEGFR-2 pathway reduced growth …

Effect of ATF2 transcription factor on DLL4 gene expression in angiogenesis

K Kalyanakrishnan - 2021 - wlv.openrepository.com
… -specific ATF2 knockout mice for future in vivo studies. … The VEGF-A ligand and its isoforms
shown in Figure 1.3-B … Among all the above interactions, binding of VEGF-A165 to VEGFR2 …

Tumor-Fibroblast Interactions in Carcinomas

H Dongre, DE Costea - Biomarkers of the Tumor Microenvironment, 2022 - Springer
… Studies from in vitro organotypic skin cultures later confirmed that the effect of the … VEGF-A
and VEGF-B bind to their related receptor tyrosine kinases (RTKs), VEGFR-1 and VEGFR-2 on …

The role of CTNNB1 mutations and matrix metalloproteinases (MMPs) in anti-angiogenesis treatment of endometrial carcinoma

AA Berger, EA Kawaler, F Dao, S Misirlioglu… - Gynecologic …, 2022 - Elsevier
… secreted MMP7 potentially digests VEGFR-1, releasing VEGF-A, … Receptor (VEGFR)-2,
Neuropilin (NRP)-1/2, Placental … signaling via VEGF-A receptors, as well as interaction with other …

Mathematical modelling for spatial optimization of irradiation during proton radiotherapy with nanosensitizers

M Kuznetsov, A Kolobov - Russian Journal of Numerical Analysis …, 2023 - degruyter.com
… stimulating interactions, red lines show inhibiting interactions… points were introduced on the
computational grid, marking the … non-invasive tumours in vivo. Nutrient deficiency is partially …