… protective as well as detrimental roles in patients with COVID-19, … immune mediator plays a
key protective or detrimental role is … type I IFNs [50], and alveolospheres that are infected with …

… difference may provide a clinical advantage of IFN-α for the treatment of chronic HCV infection,
since type III IFNs cause less adverse hematopoietic effects than IFN-α. 55 Oh MD, Park …

… infected cells and innate immune cells. Dysregulation of host … been reported to interfere
with IFN responses are indicated. … prevent COVID-19 incidence without adverse effects, as the …

… During chronic infection and cancer, a new homeostasis is reached such that the negative
effects of IFN-Is … IFN-Is interfere with angiogenesis in three ways: They act directly on vascular …

… ISGs), which have the capacity to interfere with every step of viral replication ( … IFN-mediated
antiviral response in coronavirus infection, focusing on the innate recognition of and immune …

… , type I and III IFNs play crucial roles in innate immune … the 5′-polyuridine sequences from
negative-sense viral RNA, inhibiting … ORF6 of SARS-CoV-2 also interferes with the nuclear …

… that IFN-Is also played a negative role in antitumor immunity. … [ 55 ] These studies suggest
that IFN-α interferes simultaneously … During chronic viral infection, persistent IFN-I signaling …

… detail the role of each IFN in controlling pathogen infections in intestinal … negative regulators
used by cells to control type I IFN signaling as they can directly interact with TYK2 interfering …

… essential in the interference against viral infections across tissues… It is now understood that
IFNs play a protective role in the … in IFN promoters can be inhibited by negative transcriptional …

… antiviral immunity. In this work, we show that IFN signaling interferes with lung repair during
… localized antiviral protection at the site of infection without driving damaging proinflammatory …