… dichotomous effects of IL-1, without differentiating between IL-1β and IL-1α. … IL-1β was
underlined by studies using deficient mice or anti-IL-1 antibody, suggesting that IL-1β in the tumor …

… Non-immune and immune cells, cytokines such as IL-1β, IL-6 and tumor necrosis factor alpha
(… roles of IL-6 and the local initiation model in inflammation, autoimmunity and cancer are …

… cancer therapy. Herein, we divide currently known interleukins into 6 families, including IL-1
family, IL-2 family… -21 was broadly reported to be an essential proinflammatory mediator and …

… as interleukin-1, interleukin-6, interleukin-10, tumor necrosis … factor-β are involved in tumor
initiation and progression. Thus… IL-6 and TNF-α synergistically mediate EMT progression via …

… main mediators in the IL-1 family are the agonistic ligands IL-1α and IL-1β, with the antagonistic
ligand IL-1 receptor antagonist (IL-1RA) binding to the same receptor, IL-1R [15]. Both …

… mediators (SPM), have been identified as pivotal regulators of the initiation and resolution of
inflammation. … developed to specifically modulate inflammation in cancer therapy, with some …

… IL-1β activity and lung cancer development and provide the basis for targeting IL-1β in lung
cancer … IL-1β is a key mediator in the initiation of the inflammatory response in pulmonary …

… and is an indispensable component that orchestrates the tumor microenvironment. Studies
suggest that different mediator and cellular effectors, including cytokines (interleukins, tumor …

… tumors inflammatory cytokines like Interleukin-6 (IL-6) is highly increased and appreciable
level of IL… cells and produce inflammatory mediators, which eventually can cause cancers. …

… Inhibition of TNF can impair tumor surveillance and predispose to … of IL-1, but also of other
downstream mediators that it triggers, both protein and lipid. These mediators induced by IL-1 …