Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms
IM Salamone, M Quattrocelli… - The Journal of …, 2022 - Am Soc Clin Investig
… One month of once-weekly glucocorticoid dosing improved muscle … muscular dystrophy
(DMD) and limb girdle muscular … to muscle are likely multifold, and studies in mouse models of …
(DMD) and limb girdle muscular … to muscle are likely multifold, and studies in mouse models of …
Effects of glucocorticoids in murine models of Duchenne and limb-girdle muscular dystrophy
M Wintzinger, K Miz, A York, AR Demonbreun… - Muscular dystrophy …, 2022 - Springer
… that intermittent once-weekly dosing of glucocorticoids improved repair, fibrosis, and function
… of glucocorticoid dosing in mdx and Sgcg mice from the same DBA/2J genetic background. …
… of glucocorticoid dosing in mdx and Sgcg mice from the same DBA/2J genetic background. …
Mechanisms and clinical applications of glucocorticoid steroids in muscular dystrophy
M Quattrocelli, AS Zelikovich… - Journal of …, 2021 - content.iospress.com
… For other forms of muscular dystrophy like the limb girdle … model of muscle contusion in rats,
a high single-dose of 25 mg/kg … Thus, intermittent steroid dosing appears to mediate steroid …
a high single-dose of 25 mg/kg … Thus, intermittent steroid dosing appears to mediate steroid …
Pilot investigations into the mechanistic basis for adverse effects of glucocorticoids in dysferlinopathy
… , psoas, and gluteus muscles in the limb-girdle region and increasingly … administration,
for example, 8–10 days [44]. In contrast, we aimed to treat mice for several weeks to better …
for example, 8–10 days [44]. In contrast, we aimed to treat mice for several weeks to better …
An open label exploratory clinical trial evaluating safety and tolerability of once-weekly prednisone in becker and limb-girdle muscular dystrophy
AS Zelikovich, BC Joslin, P Casey… - Journal of …, 2022 - content.iospress.com
… randomized clinical trials showing improved muscle strength and functional outcomes [4]. …
of steroid treatment in mouse models of DMD suggest that even lower doses of intermittent …
of steroid treatment in mouse models of DMD suggest that even lower doses of intermittent …
Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model
AD Prabakaran, K McFarland, K Miz… - The Journal of …, 2024 - Am Soc Clin Investig
… intermittent prednisone administration rescued muscle quality in aged 24-month-old mice
to … the effects of chronic intermittent prednisone in muscle, we generated mice with myocyte-…
to … the effects of chronic intermittent prednisone in muscle, we generated mice with myocyte-…
Muscle mitochondrial remodeling by intermittent glucocorticoid drugs requires an intact circadian clock and muscle PGC1α
M Quattrocelli, M Wintzinger, K Miz, DC Levine… - Science …, 2022 - science.org
… that intermittent once-weekly prednisone improved nutrient … intermittent dosing of
glucocorticoids such as prednisone … with intermittent weekly regimens, we treated a subset of mice …
glucocorticoids such as prednisone … with intermittent weekly regimens, we treated a subset of mice …
Anti-RANKL therapy prevents glucocorticoid-induced bone loss and promotes muscle function in a mouse model of Duchenne muscular dystrophy
… the structural maintenance of bones [… improved skeletal muscle function and prevented
steroid-induced bone loss. We also aimed to establish whether administration of repeated doses …
steroid-induced bone loss. We also aimed to establish whether administration of repeated doses …
Serum protein and imaging biomarkers after intermittent steroid treatment in muscular dystrophy
AB Willis, A Zelikovich, R Sufit, S Ajroud-Driss… - medRxiv, 2024 - medrxiv.org
… prednisone in patients with Limb Girdle and Becker muscular dystrophy (LGMD and …
mouse models of DMD and LGMD 7,8. We identified that once weekly steroids improved muscle …
mouse models of DMD and LGMD 7,8. We identified that once weekly steroids improved muscle …
[HTML][HTML] Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy
ZM Howard, CK Gomatam, CP Rabolli, J Lowe… - JCI insight, 2022 - ncbi.nlm.nih.gov
… that are only partially mitigated by intermittent treatment regimens (5–… , may improve DMD to
a less severe Becker muscular … From the treated mice, we analyzed skeletal muscle cytokine …
a less severe Becker muscular … From the treated mice, we analyzed skeletal muscle cytokine …