In Situ Single-Pass Intestinal Perfusion in Rats for Intestinal Permeability Investigation of Drugs.
W Huang, S Chen, L Sun, H Wang… - Indian Journal of …, 2023 - search.ebscohost.com
… in situ single-pass intestinal perfusion method in rats for intestinal permeability investigation
… In this work, the predicted Fabs of metformin and ranitidine using above-mentioned equation …
… In this work, the predicted Fabs of metformin and ranitidine using above-mentioned equation …
Optimized in silico modeling of drug absorption after gastric bypass: The case of metformin
A Dahan, D Porat, M Markovic, M Zur, O Kister… - Pharmaceutics, 2021 - mdpi.com
… region-dependent permeability of metformin, using the rat single-pass intestinal perfusion
method (… The weight but also the disease burden have an impact on intestinal permeability and …
method (… The weight but also the disease burden have an impact on intestinal permeability and …
Meta-assessment of metformin absorption and disposition pharmacokinetics in nine species
YS Jeong, WJ Jusko - Pharmaceuticals, 2021 - mdpi.com
… Therefore, expecting that intestinal permeability is the major determinant … a single-pass
intestinal perfusion study in rats [33], P e f f , r a t was lower at a higher concentration of metformin …
intestinal perfusion study in rats [33], P e f f , r a t was lower at a higher concentration of metformin …
A Newly Developed and Fully Validated HPLC Method for Simultenous Determination of in-situ Single Pass Intestinal Permeability of Domperidone, Metoprolol …
… common rat perfusion techniques—(a) single-pass intestinal … red in samples from rat intestinal
permeability studies: HPLC … for simultaneous determination of metformin hydrochloride, …
permeability studies: HPLC … for simultaneous determination of metformin hydrochloride, …
In situ evaluation of the impact of metformin or verapamil coadministration with vildagliptin on its regional absorption from the rabbit's intestine
… concentrations, enhancing intestinal permeability and oral … from rabbit intestine adopting a
single pass intestinal perfusion … In situ intestinal perfusion in rodents: Future perspectives for …
single pass intestinal perfusion … In situ intestinal perfusion in rodents: Future perspectives for …
Influence of permeability enhancers on the paracellular permeability of metformin hydrochloride and furosemide across Caco-2 cells
… intestinal perfusion studies using suitable animal models), in vitro permeation studies using
excised intestinal … monolayer and in vivo rat system was evaluated. It was reported that all …
excised intestinal … monolayer and in vivo rat system was evaluated. It was reported that all …
Development of a RP-HPLC method for simultaneous determination of reference markers used for in-situ rat intestinal permeability studies
… Single pass intestinal perfusion is one of the most common … PR in perfusion medium. The
developed method could be helpful for researchers working on in-situ rat intestinal permeability …
developed method could be helpful for researchers working on in-situ rat intestinal permeability …
Biowaiver monographs for immediate release solid oral dosage forms: metformin hydrochloride
M Metry, Y Shu, B Abrahamsson, R Cristofoletti… - Journal of …, 2021 - Elsevier
… knockout mice had significantly lower bioavailability of metformin … Caco-2 cell monolayers
and intestinal rat perfusion, … the intestinal permeability for some poorly permeable compounds …
and intestinal rat perfusion, … the intestinal permeability for some poorly permeable compounds …
Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues
DM Zake, J Kurlovics, L Zaharenko, V Komasilovs… - PLoS …, 2021 - journals.plos.org
… data with metformin concentration distribution data in mice tissues … Intestinal permeability
demonstrated by metformin is … that metformin is not appreciably absorbed from the stomach …
demonstrated by metformin is … that metformin is not appreciably absorbed from the stomach …
Development of a pharmacokinetic model of transplacental transfer of metformin to predict in vivo fetal exposure
K Kurosawa, K Chiba, S Noguchi, T Nishimura… - Drug Metabolism and …, 2020 - ASPET
… buffer and open systems using a single-pass mode without … hours prior to the start of metformin
perfusion in the ex vivo closed … -time curve of metformin in the Oct3 −/− pregnant mice was …
perfusion in the ex vivo closed … -time curve of metformin in the Oct3 −/− pregnant mice was …