… We highlight nanoparticle design for tissue/cell targeting and controlled drug release
before discussing challenges of nanoparticle-based therapies for efficient OA and RA …

… and OA pain, we may develop innovative nanoparticles for targeting multiple tissues, such
… of current intra-articular therapies, and the advantages of nanoparticles for sustained drug …

… ) and targeted nano therapeutical molecules. The nanomaterials are primarily intra-articular …
After administration, the DDS and targeted nano therapeutical molecules can specifically …

… , micelles, and nanoparticles (NPs), have shown great potential to prolong intra-articular
residence, … with cartilage-targeted ligands for prolonged intra-articular retention. Furthermore, …

… discussed the current status of intra-articular therapy for OA treatment as well as outlined
drug … of nanotechnology will overcome the obstacles and challenges of intra-articular targeted …

… targeting could be obtained. In this review, we summarize the drugs investigated for OA
treatment … The low toxicity of nanoparticles and the improvement of articular surface erosion and …

… OA treatment, OA targeted strategies, and related signaling pathways in OA treatment are …
sites; αvβ3-targeted fumagillin nanoparticles significantly decreased inflammation and …

… with non-targeted nanoparticles, the accumulation of targeted nanoparticles in the ECM …
48 hours; the accumulation of targeted nanoparticles in chondrocytes increased by 3.7 times …

… drug targets. However, both current and new therapies can benefit from a targeted approach
… in vivo, we will include both nanoparticles and microparticles in this review and will discuss …

… With the application of nanomaterials and intelligent … in the intra-articular cavity, are also
widely used in osteoarthritis … These nanotherapeutic strategies not only improve drug targeting …