Predicting Inhaled Drug Dose Generated by Mesh Nebulizers

YC Hsu, HH Li, LC Chiu, WC Chiang… - Journal of Aerosol …, 2023 - liebertpub.com
Intra-subject variability in lung dose in healthy volunteers using five conventional portable
inhalers. J Aerosol Med 2004;17:231–238; doi: 10.1089/jam.2004.17.231 Link, Google …

Can pharmacokinetic studies assess the pulmonary fate of dry powder inhaler formulations of fluticasone propionate?

G Hochhaus, MJ Chen, A Kurumaddali, U Schilling… - The AAPS journal, 2021 - Springer
… :water at ratio of 50:5:45 %v/v as mobile phase) was used for … in the lung doses received
by the healthy volunteers when … of C to assess intra-subject variability) in separate study …

[PDF][PDF] Mephedrone: a single-dose administration study to determine human pharmacokinetics after nasal insufflation and to detect mephedrone and its metabolites in …

J Czerwinska - 2020 - kclpure.kcl.ac.uk
… six healthy male volunteers was performed to determine the distribution and pharmacokinetics
of mephedrone and its metabolites in conventional (… Inter- and intra-subject variability was …

… bioequivalence, and safety studies of gefitinib tablet formulations: a randomized, open-label, two-period, two-sequence crossover study in Chinese healthy volunteers

P Du, Z Zhao, W Yu, R Zhao, H Liu, P Li, L Liu - Journal of Drug Delivery …, 2023 - Elsevier
… for treatment of non-small cell lung cancer (NSCLC) in February 2005. … The intra-subject
variability (intra-CV) for gefitinib is … Mobile phase for gradient elution composed of water (A, 0.4% …

Dasatinib anhydrate containing oral formulation improves variability and bioavailability in humans

J Hofmann, A Bartůněk, T Hauser, G Sedmak… - Leukemia, 2023 - nature.com
Mobile phases consisted of MeOH, ammonium formate (20 mM… and reference formulations
in healthy volunteers. Test: 110.6 … therapeutic index, low intra-subject variability of PK and PK/…

Bioequivalence study of dacomitinib and Vizimpro® in healthy Chinese volunteers under fasting and fed conditions: A randomized, open‐label, single‐dose …

X Yang, J Li, T Zhang, Q Xia, W Zhang… - Clinical and …, 2023 - Wiley Online Library
healthy subjects randomly received a single 45 mg dose of test … Lung cancer has a high
incidence rate and is the primary … The coefficients of intra-subject variation for Cmax, AUC0–t, …

A novel faster-acting, dry powder-based, naloxone intranasal formulation for opioid overdose

T Lapidot, M Bouhajib, J Faulknor, S Khan… - Pharmaceutical …, 2022 - Springer
Mobile phase was prepared by dissolving of 1.36 g of sodium 1-… Assuming a 26% intra-subject
variability and a difference … well-tolerated by the healthy subjects who participated in this …

Modeling of pulmonary deposition of agents of open and fixed dose triple combination therapies through two different low-resistance inhalers in COPD: a pilot study

T Erdelyi, Z Lazar, Á Farkas, P Furi, A Nagy… - Frontiers in …, 2023 - frontiersin.org
… The Bland–Altman analysis was used to define the variabilityusing Trimbow® pMDI as
compared to healthy controls (7). In … COPD patients using numerical deposition modeling lung

Advances in soft mist inhalers

V Komalla, CYJ Wong, I Sibum… - Expert Opinion on …, 2023 - Taylor & Francis
… >50% of the dose) in the lungs, portability, and compactness, … of healthy subjects and
COPD patients and achieved lung … of fine particles reduces inter- and intra-subject variability. …

Effect of High-Fat Food on the Pharmacokinetic Profile and Safety of SAF-189s, an ALK/ROS1 Inhibitor, in Healthy Chinese Adults

H Qin, Y Tan, L Diao, AM Hui, Z Wu, Y Zhou, J Sun… - Drugs in R&D, 2023 - Springer
… mm; VWR international) with a mobile phase consisting of (A) … of 1.05, and an intra-subject
coefficient of variation (CV) of 20… healthy volunteers (3.0 vs 6.0 h), which is likely related to the …