The role of mitochondria in acute kidney injury and chronic kidney disease and its therapeutic potential

X Zhang, E Agborbesong, X Li - International journal of molecular …, 2021 - mdpi.com
… Mitochondria are intracellular organelles that contain an inner and outer membrane, with an
… connects mitochondria to other cellular organelles, including the endoplasmatic reticulum (…

Mitochondrial quality control in kidney injury and repair

C Tang, J Cai, XM Yin, JM Weinberg… - Nature Reviews …, 2021 - nature.com
… of acute kidney injury (AKI) and chronic kidney disease, as well as in abnormal … Mitochondria
are intracellular organelles that have key roles in the production of ATP, the regulation of …

Tubular mitochondrial dysfunction, oxidative stress, and progression of chronic kidney disease

M Fontecha-Barriuso, AM Lopez-Diaz… - Antioxidants, 2022 - mdpi.com
… Mitochondrial Function in Healthy Kidneys Mitochondria are intracellular organelles … ;
control cell death, inflammation, and intracellular calcium; traffic phospholipids; regulate danger …

Mitochondrial pathophysiology on chronic kidney disease

PC Braga, MG Alves, AS Rodrigues… - International journal of …, 2022 - mdpi.com
intracellular GSH content. The glutathione redox cycle is the critical antioxidant mechanism
found in several intracellular organelles… , since ascorbate can maintain intracellular GSH [273]…

The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development

T Doke, K Susztak - Trends in cell biology, 2022 - cell.com
More than 800 million people suffer from kidney disease. Genetic studies and follow-up
animal models and cell biological experiments indicate the key role of proximal tubule …

Mitochondrial redox signaling and oxidative stress in kidney diseases

AK Aranda-Rivera, A Cruz-Gregorio, OE Aparicio-Trejo… - Biomolecules, 2021 - mdpi.com
… Mitochondria are essential organelles in physiology and kidney diseases, because they … In
line with this, the redox-sensitive extracellular regulated kinase 2 (ERK2) protein mediates the …

Effects of chronic kidney disease and uremic toxins on extracellular vesicle biology

L Yaker, S Kamel, J Ausseil, A Boullier - Toxins, 2020 - mdpi.com
… in cytoplasmic proteins, organelle-associated proteins and housekeeping factors, whereas
VSMC-derived exosomes contain more cell adhesion and extracellular matrix proteins [46]. …

Mitochondrial dysfunction in kidney disease and uremic sarcopenia

K Takemura, H Nishi, R Inagi - Frontiers in Physiology, 2020 - frontiersin.org
… Mitochondria are major intracellular organelles with a variety of critical roles, such as … of
reactive oxygen species, maintenance of intracellular calcium homeostasis, and the regulation of …

Oxidative stress and mitochondrial dysfunction in chronic kidney disease

HJ Ho, H Shirakawa - Cells, 2022 - mdpi.com
… , alterations in bioenergetics, and organelle stress cause renal diseases [7]. Mitochondrial
… stress by enhancing MnSOD and inhibiting intracellular ROS generation, suggesting that …

The role of mitochondrial fission proteins in mitochondrial dynamics in kidney disease

L Qin, S Xi - International Journal of Molecular Sciences, 2022 - mdpi.com
… elevated intracellular ROS, … organelles with diverse roles and are involved in a variety of
biological functions. Mitochondria can regulate other organelles, and, in turn, other organelles