… PC2 −/− pancreatic β-cells have a defect in proinsulin … via cleavage of the CA junction
prior to cleavage at the BC junction (yielding split-65,66 proinsulin and des-64,65 proinsulin …

… proinsulin is ultimately converted to insulin and C-peptide in a 1:1 molar ratio via proteolytic
cleavages … of Ca 2+ and over a broader pH range, although its pH optimum is also 5.5 [4]. In …

… membrane to the ER lumen where it is cleaved by a signal peptidase to form proinsulin [12]. …
on Ca 2+ influx through the L-type and P/Q-type Ca V channels in rodent and human β-cells, …

… to be involved in β-cell electrical activity and potentially in the control of insulin secretion can
be … α 2 δ subunit in pancreatic β-cells, causes a 50% reduction in Ca 2+ current amplitude, …

… Ca 2+ levels and low pH, the optimal environment for the activation of endopeptidases. The
proteolytical cleavage of proinsulin by … Potential mechanisms for intraorganellar trafficking of …

… -specific manner via site-specific cleavage by prohormone … , with the β-cells of KO mice
storing higher amounts of proinsulin … -permeant CO2 and H2O via carbonic anhydrase (CA)4. …

… Here, we now show that loss of Sac2 in β cells results in excess accumulation of cholesterol
… Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two …

… of preproinsulin is cleaved to form proinsulin, which is folded … described as a pancreas-specific
zinc transporter using RT-… Newcomer ISG also appear to have high calcium sensitivity, …

… The pancreatic β-cells control insulin secretion in the body to … Within the immature ISG,
proinsulin is cleaved by prohormone … This triggered influx of calcium ions controls both duration …

… Dysfunction of the pancreatic β-cells underlies the … calcium in the regulation of protein
trafficking and proinsulin … cleavage of its N-terminal signal peptide to form proinsulin, a …