… intrathecal IgM production, their and our work consistently show that the presence of an
intrathecal IgM production … with an increased risk of conversion to multiple sclerosis (MS). Of note…

… –remitting multiple sclerosis with intrathecal IgM production might … If intrathecal IgM synthesis
is indeed a risk factor, it might interact with other risk factors associated with CIS converting …

… ITMS with a faster conversion to clinically defined multiple sclerosis (CDMS) 5,… intrathecal
IgM production >0% assessed with Reibers’ function can represent an independent risk factor …

… severity in multiple sclerosis (MS). We investigated whether … Their presence is associated
with a higher rate of conversion from … the intrathecal B-cell pool responsible for IgM production. …

… intrathecal IgM synthesis is associated with a higher likelihood of conversion from CIS to
clinically definite multiple sclerosis … of intrathecal IgM production is associated with a first choice …

… second relapse, the development of early disability, and conversion to SPMS. Thus, … risk of
progression who would be potential candidates for receiving highly effective DMTs in an early …

… > 58 as an independent risk factor for reaching an EDSS of 3 … be involved in the intrathecal
production of immunoglobulins, … and predicts earlier conversion to secondary progressive MS …

… intrathecal IgM synthesis is a risk factor for a second relapse or MRI activity. It was not
associated with higher disability in patients after the first … several other calculation methods with …

… relapse or converting to clinically definite MS (if the conversion was … intrathecal IgM also
had restricted IgG oligoclonal bands. Moreover, our study confirmed that OCGBs are a risk factor …

… Our group demonstrated that intrathecal oligoclonal IgM bands (OCMB) were a risk factor for
early conversion to MS2 and also for increase in T2 lesions and early brain atrophy on …