Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain
TS Nelson, GP Sinha, DFS Santos… - Proceedings of the …, 2022 - National Acad Sciences
… the anti-hyperalgesic effects of the intrathecal Y1 agonist. We … induction of both neuropathic
and inflammatory allodynia (28)… reduced both neuropathic behavioral and spinal molecular …
and inflammatory allodynia (28)… reduced both neuropathic behavioral and spinal molecular …
Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch
… neuropeptide Y (NPY… intrathecal administration of Y1 agonists) to inhibit mechanical and
thermal hypersensitivity and spinal neuron activity in rodent models of neuropathic, inflammatory…
thermal hypersensitivity and spinal neuron activity in rodent models of neuropathic, inflammatory…
[HTML][HTML] Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp
… genes implicated in neuropathic and inflammatory mechanical … intrathecal Y1 agonists act
at GRP-INs to inhibit neuropathic … and potently reduce the behavioral signs of neuropathic pain …
at GRP-INs to inhibit neuropathic … and potently reduce the behavioral signs of neuropathic pain …
[HTML][HTML] mTOR–neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain
… Moreover, mTOR-mediated metabolic reprogramming was required for induction of inflammatory
… We found that Mtor deletion in microglia reduced microgliosis; however, it did not have …
… We found that Mtor deletion in microglia reduced microgliosis; however, it did not have …
Neuropeptide Y Y2 Receptors in Sensory Neurons Tonically Suppress Nociception and Itch but Facilitate Postsurgical and Neuropathic Pain Hypersensitivity
… We hypothesized that Y2 function depends on inflammation or nerve … Results: We report that
intrathecal BIIE0246 increased … and molecular markers of inflammatory or neuropathic pain. …
intrathecal BIIE0246 increased … and molecular markers of inflammatory or neuropathic pain. …
Mechanical and chemical itch regulated by neuropeptide YY1 signaling
…, J Chen, D Tang, W Yin, S Xu, P Gao, Y Jiao… - Molecular …, 2024 - journals.sagepub.com
… intrathecal injection could attenuate both mechanical and cold allodynia in chronic constructive
injury neuropathic … widely inhibition of neuropathic and inflammatory pain behavior. The …
injury neuropathic … widely inhibition of neuropathic and inflammatory pain behavior. The …
The neuropeptide cortistatin alleviates neuropathic pain in experimental models of peripheral nerve injury
CP Falo, R Benitez, M Caro, M Morell, I Forte-Lago… - Pharmaceutics, 2021 - mdpi.com
… (ie, neuropeptide Y, galanin, and enkephalins) in response to injury and inflammation [10]. …
100 ng in 20 µL of saline, centrally by intrathecal (it) injection in the lumbar region (between …
100 ng in 20 µL of saline, centrally by intrathecal (it) injection in the lumbar region (between …
The neuropeptide Y Y2 receptor is coexpressed with Nppb in primary afferent neurons and Y2 activation reduces histaminergic and IL-31-induced itch
… coexpress itch-associated markers such as natriuretic peptide … , intrathecal PYY 3–36 reduced
the scratch behavior induced by IL-31. Our findings imply that the NPY/Y 2 system reduces …
the scratch behavior induced by IL-31. Our findings imply that the NPY/Y 2 system reduces …
Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin A via the cAMP/PKA/p38 MAPK/CREB signaling pathway
MY Deng, J Cheng, N Gao, XY Li, H Liu… - Brain, Behavior, and …, 2024 - Elsevier
… of neuropathic pain, bone cancer pain, inflammatory pain and … Three groups of neuropathic
pain rats received intrathecal … Therefore, our results revealed that dexamethasone reduces …
pain rats received intrathecal … Therefore, our results revealed that dexamethasone reduces …
[HTML][HTML] Dynorphin and enkephalin opioid peptides and transcripts in spinal cord and dorsal root ganglion during peripheral inflammatory hyperalgesia and allodynia
… Intrathecal dynorphin administration, as well as stimulation of … Inflammation reduced
mechanical force necessary to induce … , chronic constriction injury, painful peripheral neuropathy, …
mechanical force necessary to induce … , chronic constriction injury, painful peripheral neuropathy, …