Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain

TS Nelson, GP Sinha, DFS Santos… - Proceedings of the …, 2022 - National Acad Sciences
… the anti-hyperalgesic effects of the intrathecal Y1 agonist. We … induction of both neuropathic
and inflammatory allodynia (28)… reduced both neuropathic behavioral and spinal molecular

Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch

TS Nelson, BK Taylor - Progress in neurobiology, 2021 - Elsevier
neuropeptide Y (NPY… intrathecal administration of Y1 agonists) to inhibit mechanical and
thermal hypersensitivity and spinal neuron activity in rodent models of neuropathic, inflammatory

[HTML][HTML] Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp

TS Nelson, HN Allen, P Basu, P Prasoon, E Nguyen… - JCI insight, 2023 - ncbi.nlm.nih.gov
… genes implicated in neuropathic and inflammatory mechanical … intrathecal Y1 agonists act
at GRP-INs to inhibit neuropathic … and potently reduce the behavioral signs of neuropathic pain …

[HTML][HTML] mTOR–neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain

L Chen, Y Hu, S Wang, K Cao, W Mai, W Sha, H Ma… - JCI insight, 2022 - ncbi.nlm.nih.gov
… Moreover, mTOR-mediated metabolic reprogramming was required for induction of inflammatory
… We found that Mtor deletion in microglia reduced microgliosis; however, it did not have …

Neuropeptide Y Y2 Receptors in Sensory Neurons Tonically Suppress Nociception and Itch but Facilitate Postsurgical and Neuropathic Pain Hypersensitivity

P Basu, A Maddula, TS Nelson, P Prasoon… - …, 2024 - pubs.asahq.org
… We hypothesized that Y2 function depends on inflammation or nerve … Results: We report that
intrathecal BIIE0246 increased … and molecular markers of inflammatory or neuropathic pain. …

Mechanical and chemical itch regulated by neuropeptide YY1 signaling

…, J Chen, D Tang, W Yin, S Xu, P Gao, Y Jiao… - Molecular …, 2024 - journals.sagepub.com
intrathecal injection could attenuate both mechanical and cold allodynia in chronic constructive
injury neuropathic … widely inhibition of neuropathic and inflammatory pain behavior. The …

The neuropeptide cortistatin alleviates neuropathic pain in experimental models of peripheral nerve injury

CP Falo, R Benitez, M Caro, M Morell, I Forte-Lago… - Pharmaceutics, 2021 - mdpi.com
… (ie, neuropeptide Y, galanin, and enkephalins) in response to injury and inflammation [10]. …
100 ng in 20 µL of saline, centrally by intrathecal (it) injection in the lumbar region (between …

The neuropeptide Y Y2 receptor is coexpressed with Nppb in primary afferent neurons and Y2 activation reduces histaminergic and IL-31-induced itch

H Ma, T Gao, JET Jakobsson, HM Weman, B Xu… - … of Pharmacology and …, 2020 - ASPET
… coexpress itch-associated markers such as natriuretic peptide … , intrathecal PYY 3–36 reduced
the scratch behavior induced by IL-31. Our findings imply that the NPY/Y 2 system reduces

Dexamethasone attenuates neuropathic pain through spinal microglial expression of dynorphin A via the cAMP/PKA/p38 MAPK/CREB signaling pathway

MY Deng, J Cheng, N Gao, XY Li, H Liu… - Brain, Behavior, and …, 2024 - Elsevier
… of neuropathic pain, bone cancer pain, inflammatory pain and … Three groups of neuropathic
pain rats received intrathecal … Therefore, our results revealed that dexamethasone reduces

[HTML][HTML] Dynorphin and enkephalin opioid peptides and transcripts in spinal cord and dorsal root ganglion during peripheral inflammatory hyperalgesia and allodynia

MR Sapio, MJ Iadarola, AJ Loydpierson, JJ Kim… - The Journal of pain, 2020 - Elsevier
Intrathecal dynorphin administration, as well as stimulation of … Inflammation reduced
mechanical force necessary to induce … , chronic constriction injury, painful peripheral neuropathy, …