[HTML][HTML] The molecular mechanisms of iron metabolism and its role in cardiac dysfunction and cardioprotection

T Ravingerová, L Kindernay, M Barteková… - … journal of molecular …, 2020 - mdpi.com
… In humans, dysregulation of iron metabolism can result in both low and high iron levels.
Iron deficiency is frequently present in heart failure patients with reduced ejection fraction …

Iron metabolism: pathophysiology and pharmacology

K Roemhild, F von Maltzahn, R Weiskirchen… - Trends in …, 2021 - cell.com
… the involvement of deregulated iron homeostasis (ie, iron deficiency and iron overload) in …
iron metabolism, discussing therapeutic strategies that are either already used in the clinic

[HTML][HTML] The clinical significance of iron overload and iron metabolism in myelodysplastic syndrome and acute myeloid leukemia

S Weber, A Parmon, N Kurrle, F Schnütgen… - Frontiers in …, 2021 - frontiersin.org
… In this review, we will first give an overview of the molecular basis of iron metabolism and its
… on the altered iron metabolism in MDS and AML patients including clinical consequences. …

[HTML][HTML] Iron metabolism in obesity and metabolic syndrome

Á González-Domínguez, FM Visiedo-García… - … journal of molecular …, 2020 - mdpi.com
… Obesity has been found to influence every step of iron metabolism. Furthermore, the …
relationship between obesity and iron metabolism from a molecular and mechanistic point …

[HTML][HTML] Iron metabolism and iron disorders revisited in the hepcidin era

C Camaschella, A Nai, L Silvestri - Haematologica, 2020 - ncbi.nlm.nih.gov
… presence of iron-replete macrophages. Our improved understanding of iron homeostasis and
… of oral iron treatment and the choice of oral versus intravenous iron in the management of …

The molecular mechanisms of copper metabolism and its roles in human diseases

J Chen, Y Jiang, H Shi, Y Peng, X Fan, C Li - Pflügers Archiv-European …, 2020 - Springer
… In peripheral tissue cells, cuprous ions are either sequestrated by molecules such as … Copper
metabolism must be tightly controlled in order to achieve homeostasis and avoid disorders. …

Mechanisms controlling cellular and systemic iron homeostasis

B Galy, M Conrad, M Muckenthaler - Nature Reviews Molecular Cell …, 2024 - nature.com
iron fluxes between different compartments. Although, historically, cellular and systemic control
of iron homeostasis were … systems affect systemic iron homeostasis. This topic has major …

[HTML][HTML] Iron in infection and immunity

M Nairz, G Weiss - Molecular Aspects of Medicine, 2020 - Elsevier
… important interconnections between iron metabolism and immunity, focusing on host defense
against relevant infections and on the clinical consequences of anemia of inflammation. …

[HTML][HTML] Iron and chelation in biochemistry and medicine: new approaches to controlling iron metabolism and treating related diseases

GJ Kontoghiorghes, CN Kontoghiorghe - Cells, 2020 - mdpi.com
… Characterization of the molecular mechanisms on iron chelation, as well as in vitro and in
vivo studies and also following clinical findings could have an impact on determining the …

[HTML][HTML] Altered iron metabolism and impact in cancer biology, metastasis, and immunology

RAM Brown, KL Richardson, TD Kabir, D Trinder… - Frontiers in …, 2020 - frontiersin.org
… This review will explain cellular iron metabolism and homeostasis mechanisms that go
awry to support tumor growth and progression as well as potential iron-based therapeutic …