[HTML][HTML] The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma

B Tang, J Zhu, J Li, K Fan, Y Gao, S Cheng… - Cell Communication and …, 2020 - Springer
… As it was determined that erastin inhibited the proliferation and progression of HCC, we
explored the possible molecular mechanism by which erastin achieves antitumor effects. In the …

Crosstalk between macrophages, T cells, and iron metabolism in tumor microenvironment

L Shen, Y Zhou, H He, W Chen… - Oxidative Medicine …, 2021 - Wiley Online Library
… proving the role of iron in tumor development, metastasis, and TME modification [13, 14].
In this review, we briefly introduce the pathophysiology of iron metabolism and leukocytes, …

The detrimental effect of iron on OA chondrocytes: Importance of pro‐inflammatory cytokines induced iron influx and oxidative stress

X Jing, T Du, T Li, X Yang, G Wang… - … and molecular …, 2021 - Wiley Online Library
… the roles of iron homeostasis and iron overload mediated … chondrocytes iron homeostasis
via upregulating iron influx … molecular mechanisms of OA still remain poorly understood. …

[HTML][HTML] ACSL4 as a potential target and biomarker for anticancer: from molecular mechanisms to clinical therapeutics

J Hou, C Jiang, X Wen, C Li, S Xiong, T Yue… - Frontiers in …, 2022 - frontiersin.org
… in some genes that regulate iron homeostasis and lipid peroxidation metabolism. In the … )
exhaustion, cystine deprivation and abnormal iron metabolism. As for anti-ferroptosis pathway, …

Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications

A Frtús, B Smolková, M Uzhytchak, M Lunova… - Journal of controlled …, 2020 - Elsevier
molecular mechanisms of IONPs-cell interactions will provide a basement to increase the
likelihood for clinical … Indeed, normal iron homeostasis is mediated through iron absorption, …

[HTML][HTML] Mechanism of ferroptosis and its relationships with other types of programmed cell death: insights for potential interventions after intracerebral hemorrhage

SY Zhou, GZ Cui, XL Yan, X Wang, Y Qu… - Frontiers in …, 2020 - frontiersin.org
… Here, we focus on the potential targets, including iron metabolism, GSH biosynthesis, and …
molecules are known to regulate ferroptosis by directly or indirectly targeting iron metabolism, …

The role of iron repletion in adult iron deficiency anemia and other diseases

B Elstrott, L Khan, S Olson… - European journal of …, 2020 - Wiley Online Library
Iron absorption occurs in the duodenum and is regulated by the divalent metal transporter (…
blocks iron absorption into the circulation via ferroportin degradation and inhibits iron release …

Mechanisms of mitochondrial iron-sulfur protein biogenesis

R Lill, SA Freibert - Annual review of biochemistry, 2020 - annualreviews.org
molecular mechanisms underlying the ISC protein–mediated maturation of mitochondrial
Fe/… /S cluster–dependent processes encompass the regulation of cellular iron homeostasis by …

[HTML][HTML] Regulation of tissue iron homeostasis: the macrophage “ferrostat”

NC Winn, KM Volk, AH Hasty - JCI insight, 2020 - ncbi.nlm.nih.gov
iron homeostasis, supplying or sequestering iron as needed for erythropoiesis or bacteriostasis,
respectively. Indeed, recycling of iron … the molecular mechanisms that govern iron cycling…

[HTML][HTML] Effects of maternal iron status on placental and fetal iron homeostasis

V Sangkhae, AL Fisher, S Wong… - … Journal of clinical …, 2021 - Am Soc Clin Investig
… The authors identified molecular mechanisms that limit placental ability to upregulate … of
iron deficiency of the materno-fetal unit. We present evidence that placental iron homeostasis is …