Assessment of culture/preservation conditions of human islets for transplantation

Y Shindo, J Kalivarathan, PB Saravanan… - … Transplantation, 2022 - journals.sagepub.com
… or preservation of islets before transplantation is required to … effect of islet preservation on
viability and function of islets when … to identify optimal culture/preservation conditions that result …

Optimal Time to Ship Human Islets Post Tissue Culture to Maximize Islet Recovery

BJ Olack, M Alexander, CJ Swanson… - … Transplantation, 2020 - journals.sagepub.com
… In summary, we determined that an increased duration of 37C culture time for human islets
prior to overnight shipping may reduce islet loss experienced by investigator recipients. This …

Advances in pancreatic islet transplantation sites for the treatment of diabetes

F Cayabyab, LR Nih, E Yoshihara - Frontiers in endocrinology, 2021 - frontiersin.org
… days before the islet develops a functional vasculature (111), but even then, the transplanted
islets … In addition, islets transplanted in the epidermal fat site have lower, controlled glucose …

Semi-automated assessment of human islet viability predicts transplantation outcomes in a diabetic mouse model

M Salgado, N Gonzalez, L Medrano… - … transplantation, 2020 - journals.sagepub.com
… , Aliso Viejo, CA, USA) until they were distributed for analyses. … of isolated islets: islet
count (post-isolation islet equivalent … use of clinical islet transplantation data, before it can be …

Failure mode and effect analysis in human islet isolation: from the theoretical to the practical risk

Q Perrier, V Lavallard, N Pernin, CH Wassmer… - Islets, 2021 - Taylor & Francis
islet transplantation procedure, including islet isolation technology, quality control, shipment
of islets … during culture medium changes or the harvesting of islets before transplantation. …

The future of clinical islet transplantation in the United States

MF Knoll, CA Knoll, R Bottino, S Bertera… - OBM Transplantation, 2021 - lidsen.com
… been a world leader in autologous islet transplantation (Tx) (ie, … world in allogeneic islet Tx
(ie, islets from deceased human … for islet xenoTx remains problematic until allogeneic islet Tx …

Trimetazidine preconditioning potentiates the effect of mesenchymal stem cells Secretome on the preservation of rat pancreatic islet survival and function In vitro

F Ahmadi, AS Lotfi, M Navaei-Nigjeh… - Applied Biochemistry and …, 2023 - Springer
… MSCs by TMZ and DZ before using their secretome in islet pre-treatment is … before
transplantation [21]. Our results indicate that pre-treatment of islets with TMZ-MSC-CCM improves …

[HTML][HTML] Contribution of a Single Islet Transplant Program to Basic Researchers in North America, Europe, and Asia through Distributing Human Islets

T Kin, D O'Gorman, W Zhai, J Moriarty, K Park… - … Transplantation, 2024 - lidsen.com
… As mentioned before, our priority is clinical transplantation, which sometimes prevents …
For logistical and operational reasons, we may have to extend a culture preservation period …

Considerations for an alternative site of islet cell transplantation

P Addison, K Fatakhova… - Journal of Diabetes …, 2020 - journals.sagepub.com
… been the de facto site of islet transplantation. Technically, this site … insulin circulation, islets
transplanted into the liver are … to the islet cell-adrenal cell culture prior to transplant have been …

[HTML][HTML] Culture on a native bone marrow-derived extracellular matrix restores the pancreatic islet basement membrane, preserves islet function, and attenuates islet …

H Wang, S Li, Q Dai, A Gonzalez, ON Tran… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
… In this study, we describe a new approach for preparing islets that enhances islet function …
, prior to islet transplantation. Compared to islets cultured on tissue culture plastic (TCP), islets