The exosomes derived from urine of premature infants target MAPK8 via miR-30a-5p to protect cisplatin-induced acute kidney injury in mice

M Ma, Q Luo, L Fan, WL Li, Q Li, Y Meng, C Yun, H Wu… - bioRxiv, 2021 - biorxiv.org
… Interestingly, human urine-derived stem cells (hUSCs) isolated from human urine were …
and cell survival [28]. Recent studies have found that kidney-derived EVs isolated from normal …

Co‐transplantation of human adipose‐derived mesenchymal stem cells with neonatal porcine islets within a prevascularized subcutaneous space augments the …

P Kuppan, K Seeberger, S Kelly, M Rosko… - …, 2020 - Wiley Online Library
… 5000-10 000 cells/cm 2 and underwent 3 passages prior to transplantation. As we previously
reported,41 MSCs isolated using this protocol express by FACS analysis the classic MSC …

Extracellular vesicles in kidney disease

C Grange, B Bussolati - Nature Reviews Nephrology, 2022 - nature.com
… A comparison of kidney-derived urinary extracellular vesicles (obtained from patients with
… Several key characteristics could potentially make stem cell-derived extracellular vesicles …

Stem Cell Derived Extracellular Vesicles to Alleviate Ischemia-Reperfusion Injury of Transplantable Organs. A Systematic Review

J Blondeel, N Gilbo, S De Bondt, D Monbaliu - Stem Cell Reviews and …, 2023 - Springer
… Although numerous pre-clinical studies have explored the effectiveness of stem cell derived
EV-therapy in treating organ IRI, the variability in stem cell sources, EV isolation techniques, …

Human induced pluripotent stem cell-derived mesenchymal stem cells acquire rejuvenation and reduced heterogeneity

W Wruck, N Graffmann, LS Spitzhorn… - Frontiers in Cell and …, 2021 - frontiersin.org
… In a hierarchical clustering analysis we could stratify the analyzed stem cells into three
meta-groups containing PSCs (embryonal and induced), MSCs of adult origin of various tissues …

The nephroprotective properties of extracellular vesicles in experimental models of chronic kidney disease: A systematic review

N Nowak, M Yamanouchi, E Satake - Stem cell reviews and reports, 2022 - Springer
… our in silico analysis showing (A) the overlap in the expression patterns of the protective
miRNAs in EVs from different cell sources (mesenchymal stem cells, endothelial cells, and urine…

Evolving Understanding of Renal Progenitor (Stem) Cells in Renal Physiology and Pathophysiology

PL Zhang, O Kroneman - Handbook of Stem Cell Applications, 2023 - Springer
… the origins of the isolated stem/progenitor cells from the cortex to the papilla. Histologically,
the isolated stem/progenitor cells are present in the distal nephron tubule, cells from the …

Allogeneic Cell Combination Therapy Ameliorates Chronic Kidney Disease-Induced Heart Failure with Preserved Ejection Fraction

AC Rieger, BA Tompkins, M Natsumeda… - Stem cells …, 2022 - academic.oup.com
… Renal intra-arterial delivery of allogeneic mesenchymal stem cells (MSCs) and kidney-derived
stem cells (KSCs) was safe and improved renal function and ameliorated diastolic …

Using Mouse Kidney Organoid Model for Nephrotoxic Drug Screening

R Liu, Y Chen, X Chen - Journal of Organoid and Bioscience, 2023 - jobs.isoor.org
… In 2009, the term "organoid" was formally proposed to refer to self-organizing 3D structures
grown and differentiated from stem cells that mimic in vivo structures and the multilineage …

Extracellular vesicles in kidney diseases: moving forward

U Erdbrügger, EJ Hoorn, TH Le, CJ Blijdorp… - Kidney360, 2023 - journals.lww.com
… recent study comparing kidney-derived uEVs (through … stem cells had a protective effect
on tubular cells in glycerol-induced AKI. Since then, stem cell–derived EVs of different stem cell