[HTML][HTML] Adverse prognostic impact of complex karyotype (≥ 3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL)

E Genescà, M Morgades, C González-Gil… - Leukemia Research, 2021 - Elsevier
Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL):
analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) …

[HTML][HTML] Prognostic impact of chromosomal abnormalities and copy number alterations in adult B-cell precursor acute lymphoblastic leukaemia: a UKALL14 study

AV Moorman, E Barretta, ER Butler, EJ Ward… - Leukemia, 2022 - nature.com
… A total of 14 (3%) patients had ALL with TCF3-PBX1 detected by karyotyping (n = 10) and/or
FISH analysis (n = 10). Karyotyping, FISH and SNP array analysis revealed the unbalanced …

Acute lymphoblastic leukaemia

F Malard, M Mohty - The Lancet, 2020 - thelancet.com
… Along with response to treatment, these abnormalities are important prognostic factors.
Disease-risk stratification and the development of intensified chemotherapy protocols …

Cytogenetic Risk Stratification of B-Acute Lymphoblastic Leukemia and Its Correlation with Other Prognostic Factors

R Chadha, DS Udayakumar, S Sangwan… - Indian Journal of …, 2023 - Springer
… 95 (BFM-95) protocol and adults on UKALL 14 protocol. In a … Normal karyotype was seen
in 219 of 1419 (15%) samples … could be analysed in all cases, normal karyotype was seen in …

[HTML][HTML] Prognostic significance of a normal karyotype in adult patients with BCR-ABL1-positive acute lymphoblastic leukemia in the tyrosine kinase inhibitor era

T Shi, H Wang, M Xie, X Li, L Zhu, X Ye - Clinics, 2020 - SciELO Brasil
SciELO - Brasil - Prognostic significance of a normal karyotype in adult patients with BCR-ABL1-positive
acute lymphoblastic leukemia in the tyrosine kinase inhibitor era Prognostic

A novel prognostic nomogram for adult acute lymphoblastic leukemia: a comprehensive analysis of 321 patients

Q Zhang, MJ Huang, HY Wang, Y Wu, YZ Chen - Annals of Hematology, 2023 - Springer
… was identified as an important prognostic factor for adult ALL. The MLL gene was first … not
be collected completely, such as chromosomal karyotype and minimal residual disease. As a …

The complex karyotype and chronic lymphocytic leukemia: prognostic value and diagnostic recommendations

L Jondreville, D Krzisch, E Chapiro… - American Journal of …, 2020 - Wiley Online Library
… In a multivariate analysis, the CK was an independent, prognostic factor for TTFT (P < .001).
Rigolin et al. suggested differentiating between two types of CK: those with major structural …

… karyotype is associated with poor outcomes in patients with Philadelphia chromosome–negative acute lymphoblastic leukemia receiving chemotherapy but not …

Z Li, Y Lai, X Zhang, L Xu, K Liu, Y Wang, C Yan… - Annals of …, 2020 - Springer
… HSK as a prognostic factor, indicating that the poor prognosis of MK was independent of the
prognostic factors for patients with ALL, as shown in our study and many other studies [27]. …

[HTML][HTML] … of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a study by the Acute Leukemia Working …

A Lazaryan, M Dolan, MJ Zhang, HL Wang… - …, 2020 - ncbi.nlm.nih.gov
… substantial overlap between complex karyotype, monosomal karyotype, and other common
… Our analysis validated other established patient- and transplant-related prognostic factors

SET-CAN fusion gene as poor prognosis predictor in adult T-cell acute lymphoblastic leukemia

Q Yang, H Qian, Z Jin, Z Yu, K Yu, S Zhang… - Leukemia & …, 2020 - Taylor & Francis
… We reported three adult T-ALL cases with SET-CAN fusion gene and two of them have
complex karyotype never previously reported ( Table 1 ). We supposed that case 2 might have a …