… advance our understanding of OA pathways as a whole. Several … Finally, we will discuss the
evolving concepts and future … -medicine can play key diagnostic and therapeutic roles in the …

… post-traumatic phases and in PTOA, and (ii) to identify key … Lastly, we discuss beneficial
infrastructure for future studies … , alternative and lectin complement pathways, are activated …

… anabolic and catabolic pathways, regenerative factors, and … vector is one key to successful
gene therapy. Many vectors – … small molecule-based drugs as well as for therapeutic nucleic …

… We concluded that the activation of the necroptotic pathway might … target for future therapeutic
strategy in OA disease. … experiments, but future approaches, including more “key players” …

… pharmacological treatments to stop excessive posttraumatic … pathways in osteoprogenitors
and mesenchymal stem cells. Some small molecules also target chronic osteoarthritis (OA) …

… future studies on developing non-invasive intervention therapies for cartilage injury post-traumatic …
An up-regulation of these cytokines trigger catabolic pathways the promote production …

… also of the key to any potential conservative or surgical therapy. … In this regard, uncertain
career development paths for basic … Genetic and small molecule-based perturbation of CCR5 …

… , to inform future basic and translational OA research. … or intraarticular fractures, causing
post-traumatic osteoarthritis (PTOA). … molecules that affect several key pathways or activities. For …

… are a major cause of post-traumatic osteoarthritis (PTOA). … Both cytokines are considered
key players in the pathogenesis … To support the current findings, future studies should employ …

… to modulate signalling pathways responsible for removing … autoimmune therapies, to be
repurposed for mitigating key … This is due to polyphenols’ important role preventing harmful …