A large-scale multicenter retrospective study on nephrotoxicity associated with empiric broad-spectrum antibiotics in critically ill patients

AY Chen, CY Deng, P Calvachi-Prieto, MÁA de la Hoz… - Chest, 2023 - Elsevier
critically ill patients in the ICU and used a more stringent definition of AKI, defined as Kidney
Disease: … ORs and 95% CIs were calculated to assess the risk of the primary and secondary

Critically Ill Health Care-Associated Urinary Tract Infection: Broad vs. Narrow Antibiotics in the Emergency Department Have Similar Outcomes

KJ Kooda, M Rudis, K Mara, C Clements… - The Journal of …, 2021 - Elsevier
… empiric therapy selection and secondary outcomes, including … ESBL coverage in all critically
ill patients presenting with HCA … Empiric broad-spectrum coverage did not affect outcome in …

Bloodstream infections in critically ill patients: an expert statement

JF Timsit, E Ruppé, F Barbier, A Tabah… - Intensive care medicine, 2020 - Springer
… with systemic signs of infection and may be either secondarylinked with an increased
hazard of acute renal failure at the … the broad-spectrum antimicrobial that was initially started. …

Ensuring target concentrations of antibiotics in critically ill patients through dose adjustment

J Gorham, FS Taccone, M Hites - Expert Opinion on Drug …, 2022 - Taylor & Francis
disorders, either secondaryrenal clearance is challenging due to the fact that we have
to take into account non-CRRT CL (renal clearance due to residual renal function plus non-renal

Risk of acute kidney injury associated with anti-pseudomonal and anti-MRSA antibiotic strategies in critically ill patients

JM Côté, M Desjardins, JF Cailhier, PT Murray… - PLoS …, 2022 - journals.plos.org
… exposure of various broad-spectrum antibiotic regimens with … these findings resulting from
secondary analyses, as many … kidney monitoring, including markers of kidney damage and …

Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)

A Abdulla, A Dijkstra, NGM Hunfeld, H Endeman… - Critical Care, 2020 - Springer
… ) as our secondary endpoints. Factors … critically ill patients may be anticipated at the bedside
using predictor variables. Male patients with apparently normal or increased renal function

Antibiotic therapy in sepsis: No next time for a second chance!

B Shahrami, M Sharif… - Journal of Clinical …, 2021 - search.ebscohost.com
… Each hour delay in the administration of appropriate broad- spectrum antibiotics … in critically
ill patients with AKI compared to those with normal renal function or end- stage renal disease

Risk of acute kidney injury in combat-injured patients associated with concomitant vancomycin and extended-spectrum β-lactam antibiotic use

JM Yabes, L Stewart, F Shaikh… - Journal of intensive …, 2021 - journals.sagepub.com
… employ broad-spectrum antimicrobials; however, antibiotic … comprised of critically ill,
combat-related trauma patients, we … evaluated the persistence of renal dysfunction. Duration of …

[PDF][PDF] … Infections in Critically Ill Patients—ESGCIP. Use of Antimicrobials for Bloodstream Infections in the Intensive Care Unit, a Clinically Oriented Review. Antibiotics …

A Tabah, J Lipman, F Barbier, N Buetti, JF Timsit - 2022 - access.archive-ouverte.unige.ch
Secondary infections are especially common in patients with … reduce the exposure to
broad-spectrum antibiotics and prevent the … Conversely, renal or hepatic dysfunction may alter the …

Prevention and management of antibiotic associated acute kidney injury in critically ill patients: new insights

I Karimzadeh, M Strader, SL Kane-Gill… - … in Critical Care, 2023 - journals.lww.com
… of kidney function, followed by a fixed maintenance dose of 60 mg q12h in patients with
impaired kidney function or … Cidofovir is a broad-spectrum antiviral that is primarily used for the …