… We have generated Dusp5 knockout (KO) rats and confirmed … KO has been shown to protect
against hypertension-induced … , renal fibrosis, medullary protein cast formation, macrophage …

… [2,3,4,5,6,7,8,9,10]. Dual-specificity protein phosphatase 5 (DUSP5) is a nuclear enzyme …
ERK 1/2) in the mitogen-activated protein kinase pathway, leading to the inactivation of ERK …

… Therefore, KO of DUSP5 protected against hypertension-induced renal injury. The roles
and … Knockout of dual-specificity protein phosphatase 5 protects against hypertension-induced …

… of hypertension-induced renal injury in SS rats is … of MMP2, and that KO of MMP2 activity
largely prevents the … nuclease knockout of dual-specificity protein phosphatase-5 enhances the …

… with raised intracellular zinc and reduced protein phosphatases. … , protein tyrosine
phosphatases (PTPs) and dual specificity … The CREB knockout in animals may provide better …

… For instance, ERK1 knockout animals appear normal and … , dual-specificity phosphatases
(DUSPs) and scaffold proteins … and suppresses the hypertension-induced cardiac hypertrophy …

… The present study evaluated the hypothesis that knockout of … (NOS) and enhances
hypertension-induced renal injury after … from BN rats versus FHH 1 BN Add3 knockout (KO) (Add3 …

… PTEN is a ubiquitous dual-specificity phosphatase and … Pten knockout mouse in 1998 by
removing exons 4 to 5, or … (AB) to mimic hypertension-induced cardiac hypertrophy in humans. …

… substitution mapping and gene knockout strategies have identified … on chromosome 13 that
can protect against salt-induced … However, further study on the knockout or transgenic rats is …

… option for treating hypertension-induced cardiac remodeling. … is increased in atherosclerotic
Ldlr knockout mice, and apoA-… There are a few dual-specificity phosphatases, including MKP…