Prophylactic cefazolin concentrations in lumbar spine surgery: a comparison of tissue and plasma cefazolin concentrations to body composition

TB Pett - 2023 - researchspace.auckland.ac.nz
weight-based system for cefazolin dosing, recommending a … Most guidelines recommend
intra-operative re-dosing after 2 … for re-dosing, and in fact sometimes do not use cefazolin half-…

Population pharmacokinetic model of cefazolin in total hip arthroplasty

J Lanoiselée, R Chaux, S Hodin, S Bourayou… - Scientific reports, 2021 - nature.com
… a population analysis of cefazolin pharmacokinetics (PK) and assess whether cefazolin
administration should be … Is tranexamic acid exposure related to blood loss in hip arthroplasty? A …

Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid

C Dorn, D Petroff, M Stoelzel, MG Kees… - Journal of …, 2021 - academic.oup.com
… The in vivo relative recovery by loss was corrected for residual tissue … re-dosing of
cefazolin’ (after 2 h), as concluded from dosingdosing is more important than timing of re-dosing. …

Cefazolin prophylaxis in spine surgery: patients are frequently underdosed and at increased risk for infection

BA Karamian, GR Toci, MJ Lambrechts, N Siegel… - The Spine Journal, 2022 - Elsevier
weight-based dose of preoperative cefazolin had an increased risk of infection following spinal
fusion surgery. Two grams prophylactic cefazolinweight-based cefazolin dose; we were …

Dosage of presurgical cefazolin in obese and non-obese patients. Does weight matter?

B Rodriguez de Castro, MM Barbosa… - Revista Espanola de …, 2020 - europepmc.org
… prophylactic dose of two grams of cefazolin between obese and non-obese patients. … a
standard prophylactic dose of two grams of cefazolin between obese and non-obese patients. …

Antibiotic prophylaxis in bariatric surgical procedures: is there an ideal antimicrobial agent?

ÁAB Ferraz, F Santa-Cruz, CE Edmiston Jr - Surgical Infections, 2020 - liebertpub.com
… in intra-operative subtherapeutic concentrations of cefazolin … patients with obesity, and
weight-based dosing could be an … that include pharmacokinetic analysis of intra-operative tissue …

[PDF][PDF] Individualized surgical antibiotic prophylaxis–why, when, and how?

D Corneci, LI Torsin, CR Filimon, NV Tănase, E Moisă… - Romanian Journal of - scumc.ro
Lack of Pharmacokinetic Basis of Weight-Based Dosing and Intra-Operative Re-Dosing
with Cefazolin Surgical Prophylaxis in Obese Patients: Implications for Antibiotic Stewardship. …

[PDF][PDF] National surgical antibiotic prophylaxis guideline in Singapore

WTG Chung, H Shafi, J Seah, P Purnima… - Ann Acad Med …, 2022 - annals.edu.sg
dosed if surgery is prolonged or there is significant blood loss… As vancomycin is less effective
than cefazolin in preventing SSI … The recommended re-dosing intervals for commonly used …

[HTML][HTML] Antibiotics in anesthesia and critical care

A Premachandra, P Moine - Annals of Translational Medicine, 2024 - ncbi.nlm.nih.gov
… o Re-dosing should be based on the half-life of the antibiotic [… : for cefazolin 3.0 g if >120
kg; for aminoglycosides, dosing is … Because intra-operative contamination may occur at any …

Comparison of 2g vs 1 g of Prophylactic Cefazolin in Surgical Site Infections in Trauma Surgery Below the Knee

FRK Sanders, RMG Kistemaker… - Foot & Ankle …, 2020 - journals.sagepub.com
pharmacokinetic and clinical results of prophylactic cefazolin … effect of a single dose of 2 g
compared with 1 g of cefazolin … , tourniquet use, estimated blood loss, fixation material, use …