Aerobic exercise training in patients with mtDNA-related mitochondrial myopathy
TD Jeppesen - Frontiers in physiology, 2020 - frontiersin.org
… Additionally, patients with mitochondrial disease due to mtDNA … oxidative capacity and
exercise tolerance. Since aerobic … high lactate level found at rest and during exercise in patients …
exercise tolerance. Since aerobic … high lactate level found at rest and during exercise in patients …
[HTML][HTML] Blood biomarkers for assessment of mitochondrial dysfunction: An expert review
WHG Hubens, A Vallbona-Garcia, IFM de Coo… - Mitochondrion, 2022 - Elsevier
… of mitochondrial impairment probably is a good strategy. This biomarker panel may assist
in the diagnosis of primary mitochondrial disease patients. As mitochondrial dysfunction may …
in the diagnosis of primary mitochondrial disease patients. As mitochondrial dysfunction may …
Molecular genetics overview of primary mitochondrial myopathies
IG Arena, A Pugliese, S Volta, A Toscano… - Journal of Clinical …, 2022 - mdpi.com
… The clinical pictures reported are usually remarkably similar, with patients often presenting
with exercise intolerance, muscle weakness and sometimes with high level of lactate at rest: …
with exercise intolerance, muscle weakness and sometimes with high level of lactate at rest: …
Safety and efficacy of omaveloxolone in patients with mitochondrial myopathy: MOTOR trial
… change in blood lactate and heart rate during submaximal exercise testing. With cycle ergometry
… Our findings of lower heart rate and reduced lactate during submaximal exercise reflect …
… Our findings of lower heart rate and reduced lactate during submaximal exercise reflect …
Diagnosing mitochondrial disorders remains challenging in the omics era
P Forny, E Footitt, JE Davison, A Lam… - Neurology …, 2021 - AAN Enterprises
… 1 out of lactate, alanine, … lactate and the other 2 plasma metabolites in nonmitochondrial
patients, the levels of alanine and proline were independent of lactate in mitochondrial disease …
patients, the levels of alanine and proline were independent of lactate in mitochondrial disease …
Increased blood lactate levels during exercise and mitochondrial DNA alterations converge on mitochondrial dysfunction in schizophrenia
… An increase in lactate occurs because the flux through glycolysis overcomes the use …
mitochondria, and the lactate stress test, which measures increased lactate during physical exercise…
mitochondria, and the lactate stress test, which measures increased lactate during physical exercise…
[HTML][HTML] Mitochondrial disorders
T Klopstock, C Priglinger, A Yilmaz… - Deutsches Ärzteblatt …, 2021 - ncbi.nlm.nih.gov
… Only a small number of these genes lie in the mitochondrial DNA; the corresponding
diseases are either maternally inherited or of sporadic distribution. The remaining disease-…
diseases are either maternally inherited or of sporadic distribution. The remaining disease-…
Diagnostic value of serum biomarkers FGF21 and GDF15 compared to muscle sample in mitochondrial disease
JM Lehtonen, M Auranen, N Darin… - … Metabolic Disease, 2021 - Wiley Online Library
… aspartyl-tRNA synthetase deficiency/leukoencephalopathy with brain stem and spinal
cord involvement and lactate elevation (DARS2); mitochondrial DNA depletion syndrome 13 (…
cord involvement and lactate elevation (DARS2); mitochondrial DNA depletion syndrome 13 (…
Mitochondrial DNA depletion syndromes
D Basel - Clinics in Perinatology, 2020 - perinatology.theclinics.com
… reason relates to the challenges in making a clear diagnosis of a mitochondrial disease. …
Spectrum of mitochondrial disease Mitochondrial disease represents a broad spectrum of …
Spectrum of mitochondrial disease Mitochondrial disease represents a broad spectrum of …
A randomized crossover trial of elamipretide in adults with primary mitochondrial myopathy
A Karaa, R Haas, A Goldstein… - Journal of cachexia …, 2020 - Wiley Online Library
Background This study aims to evaluate the effect of subcutaneous (SC) elamipretide dosing
on exercise performance using the 6 min walk test (6MWT), patient‐reported outcomes …
on exercise performance using the 6 min walk test (6MWT), patient‐reported outcomes …