… Additionally, patients with mitochondrial disease due to mtDNA … oxidative capacity and
exercise tolerance. Since aerobic … high lactate level found at rest and during exercise in patients …

… of mitochondrial impairment probably is a good strategy. This biomarker panel may assist
in the diagnosis of primary mitochondrial disease patients. As mitochondrial dysfunction may …

… The clinical pictures reported are usually remarkably similar, with patients often presenting
with exercise intolerance, muscle weakness and sometimes with high level of lactate at rest: …

… change in blood lactate and heart rate during submaximal exercise testing. With cycle ergometry
… Our findings of lower heart rate and reduced lactate during submaximal exercise reflect …

… 1 out of lactate, alanine, … lactate and the other 2 plasma metabolites in nonmitochondrial
patients, the levels of alanine and proline were independent of lactate in mitochondrial disease …

… An increase in lactate occurs because the flux through glycolysis overcomes the use …
mitochondria, and the lactate stress test, which measures increased lactate during physical exercise…

… Only a small number of these genes lie in the mitochondrial DNA; the corresponding
diseases are either maternally inherited or of sporadic distribution. The remaining disease-…

… aspartyl-tRNA synthetase deficiency/leukoencephalopathy with brain stem and spinal
cord involvement and lactate elevation (DARS2); mitochondrial DNA depletion syndrome 13 (…

… reason relates to the challenges in making a clear diagnosis of a mitochondrial disease. …
Spectrum of mitochondrial disease Mitochondrial disease represents a broad spectrum of …

Background This study aims to evaluate the effect of subcutaneous (SC) elamipretide dosing
on exercise performance using the 6 min walk test (6MWT), patient‐reported outcomes …