… in mechanical heart valves, large high-quality clinical trial data does not exist for DOACs, …
apixaban in mechanical heart valves, will further delineate the role of DOACs in this setting. …

… statistical analysis and the reasonably large sample size (2284 … in patients with heart valve
prosthesis in terms of thrombosis, … of DOACs as an alternative to VKAs in patients undergoing …

… but still high gradient persisted due … aortic bioprosthetic valves with relatively low thrombosis
risk. This suggests the need for caution in the use of DOACs in surgical bioprosthetic valve …

… , in a large retrospective analysis comparing DOACs with … showed the efficacy of DOACs in
left ventricular thrombi.[ 4,5 ] … patients with bioprosthetic mitral and/or aortic valve replacement …

… prosthetic heart valves, mechanical valves lead to a high risk … from the phase III trials comparing
DOACs with VKAs [2–5]. … thromboembolic events and thrombosis of the valve related to …

… judged at low risk of bias; at high risk of bias if one or more key domains were judged at …
events of valve thrombosis without statistically significant difference between DOACs and VKAs. …

… Characterized by rhythm irregularity, AF patients are prone to forming thrombi in the left …
with bioprosthetic heart valves (BPHV), the use of DOACs is contraindicated to a large extent, …

… therapy and the risk of thrombosis and bleeding, which may … , few patients treated with
DOACs were included in this study, … A larger-scale prospective registry study (UMIN000034485) …

… , these guidelines are based on large-scale randomized clinical … and safety of DOACs in AF
patients with an aortic BPV. The … DOACs) and type of aortic valve procedure (SAVR vs. TAVI) …

… heart valves (BHVs) and atrial fibrillation (AF). The objectives of this study were to evaluate
the ambulatory utilization of DOACs and to … In conclusion, in this large contemporary study of …