… timing of ERT initiation, as well as its effect (Figure 2). … used, such as “later-onset” in Missouri,
32 “possible LOPD” in Illinois… , we cannot use these early signs as criteria for initiating ERT, …

… , and timing of treatment initiation. This report presents a 31 5/7 weeks’ gestational age … It
predicts later onset Pompe disease. … as possible once CRIM status has been confirmed and …

… , to a highly variable, later-onset form (LOPD). Classic IOPD is … Very early initiation of treatment
with ERT leads to the best … should always have an echocardiogram as early as possible to …

… result in earlier diagnosis and enable earlier treatment initiation, which … of infants with Pompe
disease identified by newborn … A report of three later-onset patients. Mol Genet Metab. 2010;…

… Treatment beginning as soon as the disease is detected, or as early as possible, can … This
paper reports the findings from the first year of population-based Pompe disease screening. …

… very early initiation of treatment. In IOPD, treatment should be initiated as soon as possible;
… Early detection and ERT are certainly beneficial for IOPD patients, but also for less severe …

… was greater when initiated in the early stages of disease [155]. … Several hypotheses have
been proposed, including possible … The wide accessibility of newborn screening for PD around …

… IOPD should be initiated as early as possible before irreversible damage occurs. Yang et
al. indicated that early identification of patients with IOPD allows for very early initiation of ERT. …

… Early detection and initiation of treatment with enzyme … , whether treatment was initiated, and
whether the newborn … hypothyroidism, so it is possible that hypothyroidism in LOPD patients …

… Pompe disease (IOPD) to the later-onset Pompe disease (… demonstrate that the early
initiation of treatment improves the … treatment as early as possible to achieve the best treatment …