… and cardiac fibrosis are induced by SR Ca2+ leak via RyR2 in … in the context of Duchenne
muscular dystrophy (DMD). … Short-coupled polymorphic ventricular tachycardia at rest …

… gene mutations in inherited cardiac arrhythmias, in an effort … in a mouse model of Duchenne
muscular dystrophy (DMD), … of RyR2 and elevated SR Ca 2+ -leak en route to CPVT-like …

… Leaky RYR1 channels could be implicated in various … Furthermore, we reported that cardiac
arrhythmias in mdx mice can be prevented by stabilizing cardiomyocytes RYR2 channels …

… remodeling of RyR2 in the heart and RyR1 in skeletal muscle. … SR Ca 2+ release via RyR2
in cardiomyocytes is triggered … S107 which fixes the channel leak. S107 prevents calstabin …

… Ca 2+ leak was linked to ventricular arrhythmias (3). RyR2s are … Duchenne muscular dystrophy
and limb-girdle muscular … Following the discovery of the leaky RyR2 in failing hearts, we …

… related to ongoing muscle damage and the leakage of myofiber … A particular risk is carried
by ventricular arrhythmias, which … Patients with HF are at high risk of ventricular arrhythmia and …

… cardiac wall thickness, and cardiac arrhythmias [3,23]. … The initial calcium influx then triggers
a larger calcium release … of ROS and increased RyR2 calcium leak. Taken together, these …

… function in Duchenne muscular dystrophy [5, 14], … fatal hypermetabolic response to
pharmacological triggers, is not well … by mutations in the cardiac ryanodine receptor (RyR2). Due …

… triggering of cardiac arrhythmias and remodeling in DMD (5). Inhibiting the depletion of
FKBP12.6 from the RyR2 … ) stops the SR Ca 2+ leak, controls aberrant depolarization in isolated …

… We hypothesize that heightened KCNQ5 and RyR2 expression … RyR2 inhibitor, thereby
reducing calcium leakage through … agent for managing ventricular arrhythmias in DMD patients. …