… that were applied to Duchenne Muscular Dystrophy (DMD) … accumulation (likely due to
RyR leakage) and reduced ability to … Early onset DCM with lethal ventricular arrhythmias. Low …

… dystrophin protein expression eg Becker muscular dystrophy (BMD), Duchenne muscular
dystrophy … increased workload effects including cardiac arrhythmias. Therefore, microtubule …

… of severe hypotonia, muscle atrophy, and generalized … clathrin-mediated endocytosis to
trigger the fission and release … in skeletal muscle, while RyR2 encodes the cardiac ryanodine …

… , ventricular fibrillation can develop [76]. A loss of function mutation in the gene encoding
RyR2 … Duchenne muscular dystrophy, Friedreich’s ataxia, Barth syndrome, and familial atrial …

… DGC, dystrophin, causes Duchenne muscular dystrophy (DMD) … , particularly sinus tachycardia
and ventricular tachycardia, … Cyclic stretch has been shown to activate ERK1/2 and AMPK …

… result in an SR Ca 2+ leak that causes skeletal myopathies, heart … in cardiac and skeletal
muscle. RyR1 is the primary isoform in skeletal muscle, while RyR2 is the predominant cardiac …

… , likely triggering cardiac arrhythmias in mdx mice. The RyR … 2+ leak and prevented fatal
sudden cardiac arrhythmias in vivo. … of RyR2 could contribute to SR Ca 2+ leaks via RyR2 in the …

… , such as Barth syndrome [84] and Duchenne muscular dystrophy (DMD) [51]. All of these …
RYR2 can cause another arrhythmogenic disorder named polymorphic ventricular tachycardia …

… , muscular dystrophy (MD), sarcopenia, catecholaminergic polymorphic ventricular tachycardia,
… The therapeutic potential of targeting RyR2-mediated SR Ca 2+ leak for treating heart …

… insertion in the gene ryanodine receptor 2 (RYR2). Differential missplicing was observed for
… to dysfunctional DMD and manifest in Duchenne muscular dystrophy. Deletion of exon 45-…