… they are selectively spared in some muscular disorders including Duchenne's muscular …
triggers a large release of Ca2+ from the SR via RyR2 and this leads to cardiac contraction. …

… that lead to leaky RyR1 channel and skeletal muscle atrophy. … Duchenne muscular dystrophy
model, the mdx mouse … Abnormal increase of intracellular [Ca 2+ ] triggers the activation of …

… + content of cells expressing RyR2 WT and RyR2 Δβ8 – β 9, … catecholaminergic polymorphic
ventricular tachycardia (CPVT)… and leaky channels. Ca 2+ transient duration was smaller in …

… Cardiomyopathy is a leading health threat in Duchenne muscular dystrophy (DMD). Cytosolic
… More recent studies suggest DWORF may also directly activate SERCA. It is possible both …

… RyR2 leak, which is known to induce life-threatening cardiac … in the cell to activate a wide
range of intracellular processes. … -RyR2 interactions and the genesis of cardiac arrhythmia. …

… Particularly, RyR2 and SERCA seem to be related with mCU-… possible mechanism for
ventricular arrhythmia generation in … was also noticed in a Duchenne muscular dystrophy (DMD) …

… Duchenne muscular dystrophy (DMD) is caused by … since caffeine triggers Ca 2+ release
by reducing the RyR2 activation … processes, increasing the susceptibility to cardiac arrhythmia. …

… In addition, arrhythmias are frequently triggered in HCM, resulting from the high Ca 2+ -…
heart failure and ventricular arrhythmias, making HCM a notable cause of sudden cardiac death, …

… of the myocardium associated with ventricular arrhythmia (VA) [6… SR can determine the
spontaneous leakage of calcium into the … Cases of RYR2 mutations with AR inheritance have also …

… This study shows that reduced SPEG-mediated RyR2 … like catecholaminergic polymorphic
ventricular tachycardia (… AAV is effective against Duchenne muscular dystrophy and …