Roles of leptin and resistin in metabolism, reproduction, and leptin resistance

DA Zieba, W Biernat, J Barć - Domestic animal endocrinology, 2020 - Elsevier
… in which resistin downregulates leptin signaling. Potential physiological consequences of …
on leptin signaling favors the development of hyperinsulinemia to overcome insulin resistance

STAT3 phosphorylation in central leptin resistance

H Liu, T Du, C Li, G Yang - Nutrition & metabolism, 2021 - Springer
… SOCS3 inhibits the JAK2/STAT3 pathway by interacting with phospho-Y985 or JAK2 and
acting as a feedback inhibitor of leptin signaling. PTP1B also inhibits leptin signaling through …

Impaired leptin signalling in obesity: is leptin a new thermolipokine?

VA Genchi, R D'Oria, G Palma, C Caccioppoli… - International journal of …, 2021 - mdpi.com
leptin signalling by coupling to ERK kinase, all of the other four phosphatases work by inhibiting
leptin signalling, leading to leptin resistance [78]… shown to promote leptin resistance [79]. …

Multiple leptin signalling pathways in the control of metabolism and fertility: a means to different ends?

MC Evans, RA Lord, GM Anderson - International Journal of Molecular …, 2021 - mdpi.com
… promote leptin resistance. This review discusses the potential mechanisms that enable leptin
to … function in the contexts of healthy leptin signalling and of diet-induced leptin resistance. …

Central and peripheral leptin resistance in obesity and improvements of exercise

J Peng, L Yin, X Wang - Hormones and behavior, 2021 - Elsevier
… Tyr1138-STAT3 signaling also induces transcription initiation of target genes such as Socs3,
an important inhibitor of leptin signaling pathway. SOCS3 in turn blocks leptin signaling by …

[HTML][HTML] Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice

H Henneicke, S Kim, MM Swarbrick, J Li… - Molecular …, 2020 - Elsevier
… central leptin signalling in the hypothalamic arcuate nucleus (ARC) 30 min after a leptin
of skeletal glucocorticoid signalling could prevent age-related leptin resistance, we measured …

Protective effects of melatonin against obesity‐induced by leptin resistance

V Suriyagandhi, V Nachiappan - Behavioural brain research, 2022 - Elsevier
leptin secretion from adipose tissue and leptin signalling in the hypothalamus in regulating
obesity-induced leptin resistance. … Effect of Melatonin on the leptin signalling pathway in the …

Leptin signaling in obesity and colorectal cancer

CT Socol, A Chira, MA Martinez-Sanchez… - International journal of …, 2022 - mdpi.com
Leptin binding to its receptor promotes various signal transduction pathways. After the binding
process, the leptin … , which is an important event for leptin signaling and activation of the …

Leptin: less is more

S Zhao, CM Kusminski, JK Elmquist, PE Scherer - Diabetes, 2020 - Am Diabetes Assoc
leptin levels acutely restores leptin signaling, which leads to enhanced leptin signaling during
a period of reduced leptin … This fall in leptin levels, which is acutely out of proportion to fat …

Leptin signaling affects survival and chemoresistance of estrogen receptor negative breast cancer

CC Lipsey, A Harbuzariu, RW Robey, LM Huff… - International Journal of …, 2020 - mdpi.com
Leptin signaling can influence BCER− progression, but its effects on patient survival and
chemoresistance are not well understood. We hypothesize that leptin signaling decreases the …