… insulin sensitivity and whole-body glucose homeostasis [1, 2]. … CNS control of glucose
homeostasis, leptin has been shown … of leptin on glucose regulation and insulin sensitivity was …

… and human patients suggests that leptin improves insulin sensitivity in type 1 … leptin's glucose
homeostatic properties are integrated upstream of PI3K at the level of IRS. Leptin treatment …

… effects of leptin therapy in people with lipodystrophy occur independently of its hypophagic
action (133). The success of leptin therapy to improve insulin sensitivity in leptin deficient …

… system is a target of leptin to regulate energy and glucose homeostasis (9). This system …
(HFD), hyperleptinemia improves glucose metabolism and insulin sensitivity, as observed in …

… the link between insulin sensitivity, insulin resistance and … of leptin were associated with
decreased insulin sensitivity in … physiological conditions, leptin increases insulin sensitivity (14), …

… Glucose homeostasis and insulin sensitivity Glucose, mmol/L −0.061 0.669 NA NA …
Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic …

… glucose sensing disrupt in vivo glucose homeostasis in high-… leptin signalling pathways that
impact glucose homeostasis … ] enhances insulin sensitivity in lowering blood glucose levels …

… that lepb regulates glucose homeostasis and adiposity in … model to investigate the role of
leptin in the development of T2DM … , obesity, insulin resistance and impaired glucose tolerance. …

… leptin levels 2 h following CNO injection. Somewhat surprisingly, we found that CNO treatment
(… not lead to any significant changes in plasma leptin levels throughout the 2 h observation …

… comorbidities such as insulin resistance.Here … leptin action acutely improves glucose
homeostasis,17 and we could show previously that leptin potently improved glucose homeostasis …