Metformin directly binds to MMP-9 to improve plaque stability

X Chen, S Wang, W Xu, M Zhao, Y Zhang… - Journal of Cardiovascular …, 2023 - mdpi.com
… High matrix metalloproteinase-9 (MMP-9) expression and … lipid cores, intraplaque hemorrhage,
immune activation, and … , we constructed an overexpression plasmid for human MMP-9 …

Close association of matrix metalloproteinase-9 levels with the presence of thin-cap fibroatheroma in acute coronary syndrome patients: assessment by optical …

H Funayama, T Yoshioka, S Ishikawa… - Cardiovascular …, 2021 - Elsevier
… As elevated plasma matrix metalloproteinase-9 (MMP-9) levels have been documented in
… In advanced atherosclerotic lesions, MMP-9 overexpression in macrophages was shown to …

Comprehensive analysis of dysregulated genes associated with atherosclerotic plaque destabilization

C Qian, Y Jing, M Xia, Q Ye - Experimental Biology and …, 2021 - journals.sagepub.com
… plaque samples with intraplaque hemorrhage. Using gene … (CCL19) was significantly
overexpressed in unstable APs. In a … stress and material strength can promote the rupture of APs. …

The role of magnetic resonance imaging and the expression of MMP-9 protein in the analysis of carotid atherosclerotic plaques in patients undergoing carotid …

D Sef, M Milosevic, M Ostric, T Mestrovic… - Authorea …, 2021 - essopenarchive.org
Lesional overexpression of matrix metalloproteinase-9 promotes intraplaque hemorrhage
in advanced lesions but not at earlier stages of atherogenesis. Arteriosclerosis, thrombosis, …

Immunohistochemical analysis of MMP-9 and COX-2 expression in carotid atherosclerotic plaques among patients undergoing carotid endarterectomy: A prospective …

D Sef, M Kovacevic, B Jernej, K Novacic… - Journal of Stroke and …, 2022 - Elsevier
Matrix metalloproteinase-9 protein (MMP-9) and … Intraplaque haemorrhage was classified
as follows: no … hypothesized that overexpression of COX-2 in macrophages can promote the …

[HTML][HTML] The proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death

C Tengryd, SH Nielsen, M Cavalera, E Bengtsson… - Atherosclerosis, 2020 - Elsevier
… cells, macrophages and intraplaque haemorrhage were also … Matrix metalloproteinase-9
was analysed with Mesoscale … [7] and that overexpression of mimecan inhibited proliferation …

[图书][B] The Role of Type VIII Collagen in Atherosclerotic Plaque Stability

CM Harper - 2020 - search.proquest.com
… to understand the regional differences between atherosclerotic … Intraplaque hemorrhage can
promote plaque instability since … shown that overexpression of BMP2 promotes calcification, …

[PDF][PDF] Immunohistochemical analysis of MMP-9 and COX-2 expression in carotid atherosclerotic plaques among patients undergoing carotid endarterectomy: A …

MD Davorin Sef, MD Miljenko Kovacevic… - 2022 - researchgate.net
intraplaque haemorrhage was determined according to a study by Derksen et al.Intraplaque
haemorrhage … of COX-2 in macrophages can promote the development of unstable plaques. …

Anti-inflammatory actions of soluble Ninjurin-1 ameliorate atherosclerosis

S Jeon, TK Kim, SJ Jeong, IH Jung, N Kim, MN Lee… - Circulation, 2020 - Am Heart Assoc
Lesional overexpression of matrix metalloproteinase-9 promotes intraplaque hemorrhage
in advanced lesions but not at earlier stages of atherogenesis.Arterioscler Thromb Vasc Biol. …

The effect of PCSK9 inhibition on the stabilization of atherosclerotic plaque determined by biochemical and diagnostic imaging methods

M Basiak, M Hachula, M Kosowski, G Machnik… - Molecules, 2023 - mdpi.com
… a thrombus, and having intraplaque hemorrhage. There was no … In vivo overexpression of
OPN in mice caused intensified … accumulation of matrix metalloproteinase-9 was associated …