… NPM1 is a hub protein in nucleoli where it contributes to … that NPM1 mutations are later
drivers in leukemogenesis [83]. … in the case of several transcription factors and linker histone H1: …

… FOXM1, another important binding partner of nucleophosmin… , and its protein interactions
have been shown to regulate this … -α mutation is considered a primary event in leukemogenesis …

… Multifunctional characteristics of NPM1 also appear to regulate … M1(FOXM1), an oncogenic
transcription factor. A recent study … NPM1 acts as a hub protein and is involved in trafficking …

… has two major ramifications for leukemogenesis ( Figure 3 ): … other and have been described
as transcriptional hubs or factories (48–… and other proteins to regulate transcription (center). …

… Nucleophosmin (NPM1) is a ubiquitously expressed … whose overexpression leads to
leukemogenic transformation. Here, … We observed XPO1 clearly bound at key transcriptional …

… NPM1 is thus regulated by a complex interplay between … Nucleophosmin has been long
considered as a hub of the … , eg acting as a transcription factor modulated by the redox state [98]. …

… 3, NRAS, nucleophosmin 1 and DNA methyltransferase 3A, … whereas transcription factors
(TFs) regulate gene transcription by … -associated hubs in the miR-transcription factor regulatory …

… a transcription factor and has been found to bind thousands of gene promoters and regulate
… abrogates onco-MLL1′s capability of leukemogenesis. It is also noted that onco-MLL1 has …

… -regulatory networks, driven by transcription factors including PU.1 … to regulate the entire
Hoxa cluster following mutation of … induce and maintain leukemogenic transcriptional programs, …

… blockade of myeloid transcription factors interacting with … transcriptional hub regulating
terminal monocytic and neutrophil differentiation [13]. Conversely, other nuclear transcriptional …