… scientists of the day on the thermodynamics of heme protein ligand binding reactions. Abel
had a deep interest in hemoglobin and discussions with him on the latest papers from Rome …

… on sickle cell disease has had a … sickle cell anemia is not only the first human disease to
be understood at a molecular level (the first molecular disease) (2, 3), it is also the first disease …

… The issue of treating sickle cell disease with drugs that increase hemoglobin oxygen affinity
… of hemoglobin S (HbS). Treatment of sickle cell patients with voxelotor increases Hb levels …

… Valeresol showed that these compounds bind to Hb in 2:1 ratio, … ’s original finding that Hb
binds two molecules of aromatic … candidates targeting Hb for sickle cell disease drug discovery…

… the kinetics of structural and ligand-binding events on time … states due to discrete ligand
binding and dissociation events, … specification of rates for ligand binding and dissociation within …

… TRL4 is expressed on monocytes and macrophages and its ligand, lipopolysaccharide (LPS), …
Hydroxyurea increases total and fetal hemoglobin in SCD, thus reducing gelation and …

… In the sickle cell anemia, the Red Blood cells become rigid and sticky and are shape like …
The two of the docked systems differed in their ligand binding site with respect to the HbS …

… Ikuta et al. 1996, Baron 1996) and is a very active area of research especially as it relates to
fetal hemoglobin expression in sickle cell anemia; this will be discussed later in this chapter. …

… is indicative of hemoglobin’s cooperativity to ligand binding. (… to distinguish between sickle
cell anemia and sickle cell trait. … gelation (MGC), it could be determined whether hemoglobin …

… to cooperative Hb-O 2 ligand binding, as well as validating the hypothesis that Hb ligand
affinity … of sickle cell disease by its elevation in sickle RBC, which leads to further decrease in …