Ruthenium complexes for 1-and 2-photon photodynamic therapy: From in silico prediction to in vivo applications

J Karges, S Kuang, F Maschietto, O Blacque, I Ciofini… - 2020 - chemrxiv.org
… a novel approach to design Ru(II) polypyridine complexes with a red shifted 1P and …
Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy

[HTML][HTML] Bis [pyrrolyl Ru (ii)] triads: a new class of photosensitizers for metal–organic photodynamic therapy

DA Smithen, S Monro, M Pinto, J Roque… - Chemical …, 2020 - pubs.rsc.org
… and in vitro photodynamic therapy (PDT) properties of the compounds. The bis[pyrrolyl Ru(II)…
Activation of an otherwise nontoxic photosensitizer (PS) produces cytotoxic singlet oxygen ( …

Design of a tris-heteroleptic Ru (II) complex with red-light excitation and remarkably improved photobiological activity

S Li, J Zhao, X Wang, G Xu, S Gou, Q Zhao - Inorganic Chemistry, 2020 - ACS Publications
… are of increasing interest in photodynamic therapy (PDT) due to … that complex 7 showed
extraordinarily high cytotoxicity under … Ru(II)-polypyridyl complexes are known to induce DNA

Photomedicine with Inorganic Complexes: A Bright Future

MS Meijer, RM Carlos, MS Baptista… - Springer Handbook of …, 2022 - Springer
… photosensitized oxidations in photodynamic therapy (PDT) … However, many cytotoxic metal
compounds kill cells by … the testing of inorganic light-activated compounds in almost any …

[HTML][HTML] Photostable NIR emitting ruthenium (II) conjugates; uptake and biological activity in live cells

D Cullinane, KS Gkika, A Byrne, TE Keyes - Journal of inorganic …, 2020 - Elsevier
… of Ru(II)-biquinoline complexes in light activated anticancer … of live cells and intercalate
with DNA [28]. Bioconjugation of … that cytotoxicity in the case of the biquinoline complex arises …

Study of the biological activity of photoactive bipyridyl-Ru (II) complexes containing 1, 3, 5-triaza-7-phosphaadamantane (PTA).

JM Veiga Del Pino, F Scalambra… - 2023 - repositorio.ual.es
Photodynamic therapy (PDT) is based on the interaction of lightactivated photosensitising
… state of oxidation toward cytotoxic activity: case of ruthenium complexes. Computational, …

Ruthenium pyrazole complexes: a family of highly active metallodrugs for photoactivated chemotherapy

M Hirahara, A Iwamoto, Y Teraoka, Y Mizuno… - Inorganic …, 2024 - ACS Publications
… activation has been applied to photodynamic therapy (PDT), (… solutions and the cytotoxicity
of the complexes toward lung … for 20 h, and then light-activated for the indicated times using a …

Ruthenium complexes as anticancer agents: A brief history and perspectives

SY Lee, CY Kim, TG Nam - Drug design, development and therapy, 2020 - Taylor & Francis
… chemotherapy, Ru complexes as photodynamic therapy (PDT), … Thus, most of the Ru
compounds tested for their cytotoxicity … of the interactions between DNA and Ru complexes owing …

[图书][B] Synthesis and Characterization of Ruthenium and Manganese Mono-and BimetallicComplexes Towards the Photoactivated Release of Therapeutic Molecules

RN Pickens - 2022 - search.proquest.com
… of light activated molecules to deliver therapeutic agents. The … found that the complex is
stable in the dark and inhibits DNA … Continued research into the area of photodynamic therapy is …

Rationally designed long-wavelength absorbing Ru (II) polypyridyl complexes as photosensitizers for photodynamic therapy

J Karges, F Heinemann, M Jakubaszek… - Journal of the …, 2020 - ACS Publications
DNA visualized by NucBlue staining, immunofluorescence … )cytotoxicity on 2D monolayer
cells, the effect of complex 6 on … 24 h in HeLa MCTS and its cytotoxic effect was determined by …