… (eg, radiotherapy and photodynamic therapy) or indirectly (eg… -soluble, has minimal dark
cytotoxicity, is active at concentrations as … Ru(II) centers could potentiate cell death through DNA …

… to photodynamic therapy (PDT) since both therapies rely on … higher cytotoxicity compared
to the precursor complex. These … irradiation generating the active DNA photobinding agent. …

… In another study, a light-activated Ru(II) complex showed an inducible DNA-binding affinity …
therapy [27,29]. In this work, the uptake and cytotoxicity of the photoactivatable drug [Ru(bipy) …

… cytotoxicity and low resistance development are quite appealing. In this work, three Ru(II)
complexes … Thomas and coauthors also reported that Ru(II) complexes with DNA intercalating …

… Ru(II)–Pt(II) supramolecular complex, [(dip) 2 Ru(dpp)PtCl 2 ] 2+ (dpp = 2,3-bis(2-pyridyl)pyrazine),
and found it able to photobind DNA … O 2 and simultaneously form cytotoxic Pt(II) after …

… However, there are still some limitations with photodynamic therapy where therapeutic …
of cytotoxicity in the dark while also requiring a higher dosage of light to achieve the desired …

… of this thesis is light-activated metal complexes; as such, … to be cytotoxic; this process is
known as photodynamic therapy (… the DNA bases, herein we show that they interact with DNA …

… photodynamic therapy (PDT) have the potential to circumvent these issues by utilizing a
compound that is minimally toxic in the dark and in its native state, but becomes cytotoxic … DNA. …

… cytotoxicity: some compounds of Ru(III) interact with nuclear DNA, decrease RNA synthesis,
inhibit DNA … It could be applied in photodynamic therapy as a photosensitizer due to ROS …

… Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic
therapy … induced DNA photobinding in a Ru(ii)–Pt(ii) supramolecule using red light in the …